Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 33, Problem 10P
Interpretation Introduction
Interpretation:
The activation or repression of a gene, after the methylation and acetylation of lysine 27 residue should be determined.
Concept introduction:
Histones are the proteins that pack and order the DNA strands into nucleosomes. These proteins are alkaline in nature and found in eukaryotic cells. They the main proteins found in the chromatin, and around this protein DNA strands are wound. They also an important role in the gene regulation process.
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AAAGAGAAAAGAAUA
to AAAGAGAAAUGAAUA.
Suppose the codon sequence
has a single base pair mutation
If the old protein sequence was Lys-Glu-Lys-Arg-Ile, what will be the new sequence encoded by the mutant gene?
(Use the 3-letter amino acid abbreviations with hyphens and no spaces in between, i.e. Ser-Asn-Tyr-Leu-Pro.)
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- 3arrow_forwardTrue or False. Explain. A) At no time during protein synthesis does an amino acid make direct contact with the mRNA being translated. B) Because the two strands of DNA are complementary, the mRNA of a gene can be synthesized using either strand as a template.arrow_forwardPlease answer. ASAP. Thank you!arrow_forward
- True or False. Explain. Nucleosomes are aided in their formation by the high proportion of negatively-charged amino acids in histone proteinsarrow_forwardNo options are there.Fill up blanks by your knowledge.arrow_forwardTrue or False. De-acetylation of histone tails allows nucleosomes to pack together into tighter arrays, which usually reduces gene expression. Explain your answer in 1-2 sentences.arrow_forward
- Alpha polypeptide (ADH1A). Give a detailed description of its role in the disease. Describe the impact of the disease on society.Describe a way in which your gene can be manipulated to treat the disease. Assume you can make any changes to the protein product and describe specifically how it will affect its interaction with other molecules.arrow_forwardGenetics. How to identify what wrong with itarrow_forwardComplements. The sequence of part of an mRNA is 5'-AUGGGGAACAGCAAGAGUGGGGCCCUGUCCAAGGAG-3' 5'-AUGGGGAACAGCAAGAGUGGGGCCCUGUCCAAGGAG-3' What is the sequence of the DNA coding strand? Of the DNA template strand?arrow_forward
- 1arrow_forwardClose contact. Examination of the structure of DNA polymerases bound to nucleotide analogs reveals that conserved residues come within van der Waals contact of C-2'C-2' of the bound nucleotide. What is the potential significance of this interaction?arrow_forwardPlease ASAP. Thank youarrow_forward
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