Pearson eText Biology: Life on Earth with Physiology -- Instant Access (Pearson+)
12th Edition
ISBN: 9780135755785
Author: Gerald Audesirk, Teresa Audesirk
Publisher: PEARSON+
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Chapter 37.2, Problem 1CSC
If phagocytes kill most species of bacteria that enter mucous membranes or a wound, how did infection kill Jim Henson and destroy Aimee Copeland’s tissues? Both S pyogenes and deadly strains of A. hydrophila are surrounded by polysaccharide capsules that phagocytic cells often do not recognize as foreign. Consequently, the phagocytes do not attack these bacteria. If such nonspecific defenses fail, can the adaptive immune response step in?
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What is a cytokine?
A
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The classical complement pathway is initiated by C1q binding to the surface of a pathogen. In some cases, C1q can directly bind the pathogen, for instance by recognizing proteins of bacterial cell walls, but in most cases C1q binds to IgM antibodies that are bound to the pathogen surface. How does this IgM-binding feature of C1q contribute to rapid, innate immune responses rather than to slow, adaptive responses?
C1q induces B lymphocytes to begin secreting antibody within hours of pathogen exposure.
Natural antibody that binds to many microbial pathogens is produced prior to pathogen exposure.
C1q binds to C-reactive protein which then binds to IgM on the pathogen surface.
C1q directly induces inflammation, recruiting phagocytes and antibodies from the blood into the infected tissue.
C1q binds to dendritic cells in the infected tissue, inducing them to secrete inflammatory cytokines.
Mycobacteria are intracellular pathogens that have adapted to life inside phagocytic cells, such as macrophages. These intracellular bacteria are taken up by phagocytosis, similar to other pathogens, but the bacteria are not killed. One possible mechanism that could account for this immune evasion by mycobacteria is their ability to:
Prevent induction of nitric oxide production in the phagosome
Prevent the acidification of phagosomes
Prevent the expression of antimicrobial peptides in the phagosome
Prevent fusion of phagosomes with lysosomes
Kill the macrophage before it kills them
Chapter 37 Solutions
Pearson eText Biology: Life on Earth with Physiology -- Instant Access (Pearson+)
Ch. 37.1 - compare and contrast the terms microbe and...Ch. 37.1 - Prob. 2CYLCh. 37.2 - Prob. 1TCCh. 37.2 - If phagocytes kill most species of bacteria that...Ch. 37.2 - describe the external barriers to Infection,...Ch. 37.2 - Prob. 2CYLCh. 37.3 - Prob. 1CYLCh. 37.3 - Prob. 2CYLCh. 37.4 - Prob. 1TCCh. 37.4 - Prob. 1CYL
Ch. 37.4 - Prob. 2CYLCh. 37.4 - Prob. 3CYLCh. 37.5 - Prob. 1CYLCh. 37.5 - Prob. 2CYLCh. 37.6 - Prob. 1CYLCh. 37.6 - Prob. 2CYLCh. 37.7 - Prob. 1HYEWCh. 37.7 - Prob. 1TCCh. 37.7 - explain how antibiotics, antiviral drugs, and...Ch. 37.7 - Prob. 2CYLCh. 37.8 - What might be the evolutionary advantage of...Ch. 37.8 - Prob. 1CYLCh. 37.9 - Prob. 1CYLCh. 37.9 - describe current medical treatments against...Ch. 37.9 - Prob. 1CTCh. 37 - Prob. 1MCCh. 37 - Prob. 2MCCh. 37 - Molecules that label your cells as self are a....Ch. 37 - Prob. 4MCCh. 37 - The immune system usually does not attack your...Ch. 37 - External defenses against microbial invasion...Ch. 37 - Prob. 2FIBCh. 37 - Prob. 3FIBCh. 37 - Prob. 4FIBCh. 37 - Prob. 5FIBCh. 37 - Prob. 6FIBCh. 37 - Prob. 1RQCh. 37 - Prob. 2RQCh. 37 - Describe humoral immunity and cell-mediated...Ch. 37 - Prob. 4RQCh. 37 - Prob. 5RQCh. 37 - Prob. 6RQCh. 37 - Prob. 7RQCh. 37 - What are memory cells? How do they contribute to...Ch. 37 - Prob. 9RQCh. 37 - Prob. 10RQCh. 37 - Prob. 11RQCh. 37 - Prob. 12RQCh. 37 - Prob. 13RQCh. 37 - Why is it essential that antibodies and T-cell...Ch. 37 - Prob. 2AC
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