CAMP.BIOL.CONC.&CONN.V.1 W/MAST.BIOL>C
15th Edition
ISBN: 9781269867122
Author: Reece
Publisher: PEARSON C
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Textbook Question
Chapter 4, Problem 16TYK
Describe the pathway of the protein hormone insulin from its gene to its export from a cell of your pancreas.
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Chapter 4 Solutions
CAMP.BIOL.CONC.&CONN.V.1 W/MAST.BIOL>C
Ch. 4 - Label the structures in this diagram of an animal...Ch. 4 - Prob. 2TYKCh. 4 - Prob. 3TYKCh. 4 - Which of the following clues would tell you...Ch. 4 - Prob. 5TYKCh. 4 - What four cellular components are shared by...Ch. 4 - Describe two different ways in which cilia can...Ch. 4 - In which cell would you find the most lysosomes?...Ch. 4 - Prob. 9TYKCh. 4 - Prob. 10TYK
Ch. 4 - In which cell would you find the most...Ch. 4 - In what ways do the internal membranes of a...Ch. 4 - Is this statement true or false? Animal cells have...Ch. 4 - Describe the structure of the plasma membrane of...Ch. 4 - Prob. 15TYKCh. 4 - Describe the pathway of the protein hormone...Ch. 4 - How might the phrase ingested but not digested be...Ch. 4 - Cilia are found on cells in almost every organ of...Ch. 4 - SCIENTIFIC THINKING Microtubules often produce...
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- Effect of BPA on Insulin Secretion Bisphenol A (BPA) is an endocrine disruptor that may increase the risk of type 2 diabetes. Angel Nadal suspected that BPA disrupts insulin metabolism by activating an estrogen receptor on pancreatic islet cells. FIGURE 34.11 shows the results of one experiments. Cultured cells from human pancreatic islets were exposed either to BPA or to DPN, a chemical that binds to the estrogen receptor and activates it. Cells were then exposed to glucose, and their insulin Secretion was monitored. FIGURE 34.11 Effects of BPA and DPN on glucose-stimulated insulin secretion. DPN is a chemical known to bind and activate estrogen receptors on pancreatic cells. A glucose concentration of 8 millimolar (mM) is equivalent to that of the blood after a meal. Is this data consistent with the hypothesis that BPA alters human insulin secretion by binding to and activating the estrogen receptor?arrow_forwardEffect of BPA on Insulin Secretion Bisphenol A (BPA) is an endocrine disruptor that may increase the risk of type 2 diabetes. Angel Nadal suspected that BPA disrupts insulin metabolism by activating an estrogen receptor on pancreatic islet cells. FIGURE 34.11 shows the results of one experiments. Cultured cells from human pancreatic islets were exposed either to BPA or to DPN, a chemical that binds to the estrogen receptor and activates it. Cells were then exposed to glucose, and their insulin Secretion was monitored. FIGURE 34.11 Effects of BPA and DPN on glucose-stimulated insulin secretion. DPN is a chemical known to bind and activate estrogen receptors on pancreatic cells. A glucose concentration of 8 millimolar (mM) is equivalent to that of the blood after a meal. How were the effects or DPN and BPA similar? How did they differ?arrow_forwardOutline the steps of the steps in the production of insulin by bacteria.arrow_forward
- In severely diabetic patients, the blood glucose level is so high that it appears in the urine. Before the development of blood tests by modern medical research, diabetics could often be recognized by the appearance of flies around their feet. Suggest a reason for this observation.arrow_forwardOne such laboratory study investigated the binding of a hormone to three different receptor proteins in the cell membrane. The data collected are shown in the table below 1) Provide a brief explanation as to why ligand binding toproteins must be a reversible process. 2) Calculate the dissociation constant (Kd) for the hormone binding to each of the three proteins.arrow_forwardIn type II diabetes, insulin is produced but is nonfunctional. These patients are described as “starving in a sea of plenty,” because their blood glucose levels are high, but none of the glucose is transported into the cells. Describe how this leads to malnutrition.arrow_forward
- Ligand-activated receptors should be ________ before they can bind DNA and activate transcription. a. dephosphorylated b. phosphorylated c. bound by their metabolite ligand d. bound by their hormone ligandarrow_forwardDiabetes often results in the production of reduced levels of insulin. Researchers claim that a drug that binds to and blocks the active site of GSK3 might mimic the role of insulin in the pathway shown in Figure 2. Provide reasoning to justify the researchers' claim.arrow_forwardRegulation in biological systems depends on feedback .which is an exmple of in formation flow. when diabbetes destroy insulin-producing cells, what infortamtion flow in disrupted? The body is unable to send signals that indicate the amount of sugar in the blood. Cells in the bladder are no longer able to send signals when the blodder fills. Appetite signals no longer regulate feeding . The pancres is unable to produce enzymes to break down protein.arrow_forward
- Explain the functions of insulin. Why do you think a hormone such asinsulin is required to carry out these functions?arrow_forwardName three metabolic processes in the cell that are enhanced and two that are inhibited in response to the hormone insulin.arrow_forwardThe glycolytic pathway is regulated by a number of key enzymes. Describe the various substrates and hormones that act on these enzymatic steps and the type of regulation (e.g. allosteric etc.).arrow_forward
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