Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Chapter 43, Problem 15PIAT
Summary Introduction
To review:
The effects of removing extracellular sodium, increasing the intracellular potassium concentration, and adding tetrodotoxin from puffer fish on the membrane potential of a neuron simultaneously poisoned with BTX (batrachotoxin).
Introduction:
The membrane potential is the electric potential difference between the interior and the surrounding fluid of the cell. The change in this membrane potential helps in the transmission of information from one cell to the other.
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Chapter 43 Solutions
Biological Science (6th Edition)
Ch. 43 - Prob. 1TYKCh. 43 - Prob. 2TYKCh. 43 - In a neuron, what creates the electrochemical...Ch. 43 - Prob. 4TYKCh. 43 - Explain the difference between a ligand-gated K+...Ch. 43 - Prob. 6TYUCh. 43 - Prob. 7TYUCh. 43 - Prob. 8TYUCh. 43 - Prob. 9TYPSSCh. 43 - Alzheimer’s disease is a common form of dementia...
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- • Why would one use the Goldman-Hodgkin-Katz equation? • What is the role of the Na+/K+ pump in establishing ionic concentration differences and membrane potentials across the nerve membrane? • Describe the process of depolarization of the nerve membrane.arrow_forwardBriefly explain the difference between a receptor antagonist and a receptor inverse agonist. Describe both the resulting receptor conformation as well as the signal transduction.arrow_forwardDescribe the distribution of voltage gated ion channels in the nodes of Ranvier-vs-trigger zone/axonarrow_forward
- Name a drug for treatment for overactive bladder syndrome which does not target the muscarinic M3 receptors directly, but rather targets one of the second messenger signalling molecules within the smooth muscle cells as a result of muscarinic M3 receptor activation. Which second messenger molecule would you choose to target? Justify your choice and explain how targeting this second messenger pathway would result in the reduction of bladder smooth muscle contraction.arrow_forwardAMPK and mTOR can both be considered intracellular signal integrators. Explain this definition.arrow_forwardDesign a novel drug for treatment for overactive bladder syndrome which does not target the muscarinic M3 receptors directly, but rather targets one of the second messenger signalling molecules within the smooth muscle cells as a result of muscarinic M3 receptor activation. Which second messenger molecule would you choose to target? Justify your choice and explain how targeting this second messenger pathway would result in the reduction of bladder smooth muscle contraction.arrow_forward
- Batrachotoxin (BTX) is a steroidal alkaloid from the skin of Phyllobates terribilis , a poisonous Colombian frog (the source of the poison used on blowgun darts). In the presence of BTX, Na+ channels in an excised patch stay persistently open when the membrane is depolarized. They close when the membrane is repolarized . Which transition is blocked by BTX?arrow_forwardIf neurons fire action potentials when membrane potential reaches -50mV, how would hyperkalemia affect neuronal excitability (likelihood of the neuron firing action potentials)?arrow_forwardSecond-messenger systems ultimately bring about the desired cell response by inducing a change in the shape and function of particular designated intracellular proteins. (True or false?)arrow_forward
- If a postsynaptic cell has synapses from five different cells, and three cause EPSPs and two of them cause IPSPs, give an example of a series of depolarizations and hyperpolarizations that would result in the neuron reaching threshold.arrow_forwardOutline the three general means by which binding of a water soluble extracellular chemical messenger to its matching surface membrane receptor brings about the desired intracellular response.arrow_forwardAstrocytes use _______ ______ to convert glutamate and NH4 into _______ for neuron re-uptake. mitochondria, ATP glutamine synthase, glutamine action potentials, voltage glycine, glucosearrow_forward
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