ANATOMY & PHYSIOLOGY: THE UNITY OF FORM
9th Edition
ISBN: 9781264489251
Author: SALADIN
Publisher: MCG
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Chapter 4.4, Problem 9AYLO
Summary Introduction
To discuss:
What polygenic inheritance and pleiotropy suggest about the relationship between a certain
Introduction:
DNA is a genetic material consisting of a long stretch of
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Suppose a maternal effect gene exists as a functional dominantallele and a nonfunctional recessive allele. A mother who is phenotypically abnormal produces all normal offspring. Explain thegenotype of the mother
F1 and F2 offspring with given genders and disease phenotypes.
The data are generated from an initial parental cross.
One parent displays the disease phenotype and one displays the wild-type (WT) phenotype.
The WT parent always has a homozygous genotype.
There are three possible modes of inheritance that underlie
the generation of the data. All are monogenic. They are:
(i) Autosomal Recessive.
(ii) Homozygous Lethal Dominant.
(iii) Autosomal Dominant.
One's phenotype is determined by their genotype at the disease locus
and the mode of inheritance, as we have seen with Punnett Square.
on the F2 data and make a decision, based on your statistical analysis, as to whether
you reject or do not reject the computer-generated model of inheritance as being consistent
with the observed data.
The mode of inheritance you are to test on the observed data is autosomal recessive.
PARENTAL CROSS
Parental cross: Father with disease phenotype, Mother with wild-type phenotype.
F1 DATA
Phenotype…
Mutations in DNA that result in altered proteins can causehereditary diseases. Pedigree studies and genetic testing mayclarify the risk of disease. At the chromosome level, nondisjunctionduring meiosis can result in gametes with too few or too manychromosomes, most of which produce inviable offspring.Imprinting refers to inactivation of alleles depending on whichparent the alleles come from; offspring in whom imprinting occursappear haploid for the affected gene even though they are diploid.
During spermatogenesis, is there any difference in outcome between first- and second-division nondisjunction?
Chapter 4 Solutions
ANATOMY & PHYSIOLOGY: THE UNITY OF FORM
Ch. 4.1 - What are the three components of a nucleotide?...Ch. 4.1 - What governs the pattern of base paring in DNA?Ch. 4.1 - what is the difference between DNA and chromatin?Ch. 4.1 - Summarize the structural and functional...Ch. 4.1 - The general name of the monomers that compose DNA...Ch. 4.1 - Prob. 2AYLOCh. 4.1 - Prob. 3AYLOCh. 4.1 - How DNA and protein are combined to form...Ch. 4.1 - Prob. 5AYLOCh. 4.1 - HOW RNA differs from DNA in structure and...
Ch. 4.2 - Prob. 5BYGOCh. 4.2 - Describe the roles of RNA polymerase ribosomes,...Ch. 4.2 - What is the difference between genetic...Ch. 4.2 - Summarize the processing of a protein from the...Ch. 4.2 - Prob. 9BYGOCh. 4.2 - Prob. 10BYGOCh. 4.2 - Prob. 1AYLOCh. 4.2 - Prob. 2AYLOCh. 4.2 - The organization of nucleotides into DNA triplets;...Ch. 4.2 - How the genetic code relates mRNA codons to...Ch. 4.2 - The process and outcome of genetic transcription,...Ch. 4.2 - Prob. 6AYLOCh. 4.2 - Prob. 7AYLOCh. 4.2 - Prob. 8AYLOCh. 4.2 - Prob. 9AYLOCh. 4.2 - Prob. 10AYLOCh. 4.3 - Describe the genetic roles of DNA helicase and DNA...Ch. 4.3 - Explain why DNA replication is called...Ch. 4.3 - Define mutation. Explain why some mutations are...Ch. 4.3 - Prob. 14BYGOCh. 4.3 - Prob. 15BYGOCh. 4.3 - Prob. 16BYGOCh. 4.3 - Prob. 1AYLOCh. 4.3 - Semiconservative replication, the enzymes that...Ch. 4.3 - What a mutation is and how a cell detects and...Ch. 4.3 - The four stages of the cell cycle, what occurs in...Ch. 4.3 - Prob. 5AYLOCh. 4.3 - Cytokinesis and how it overlaps but differs from...Ch. 4.3 - Prob. 7AYLOCh. 4.3 - Prob. 8AYLOCh. 4.4 - Why must the carrier of a genetic disease be...Ch. 4.4 - Prob. 18BYGOCh. 4.4 - Prob. 19BYGOCh. 4.4 - Prob. 1AYLOCh. 4.4 - Organization of the karyotype; the number of...Ch. 4.4 - Prob. 3AYLOCh. 4.4 - Prob. 4AYLOCh. 4.4 - Prob. 5AYLOCh. 4.4 - Why a recessive trait can skip a generation, with...Ch. 4.4 - The differences between the genotype, genome, and...Ch. 4.4 - Prob. 8AYLOCh. 4.4 - Prob. 9AYLOCh. 4.4 - Prob. 10AYLOCh. 4.4 - Prob. 11AYLOCh. 4.4 - Prob. 12AYLOCh. 4.4 - Why it cannot be said that dominant alleles are...Ch. 4.4 - Prob. 14AYLOCh. 4.4 - Prob. 15AYLOCh. 4 - Production of more than one phenotypic trait by a...Ch. 4 - When a ribosome reads a codon on mRNA, it must...Ch. 4 - Prob. 3TYRCh. 4 - Two genetically identical strands of a metaphase...Ch. 4 - Prob. 5TYRCh. 4 - Genetic transcription is performed by a....Ch. 4 - Prob. 7TYRCh. 4 - Prob. 8TYRCh. 4 - Semiconservative replication occurs during a....Ch. 4 - Mutagens sometimes cause no harm to cells for all...Ch. 4 - The cytoplasmic division at the end of mitosis is...Ch. 4 - Prob. 12TYRCh. 4 - Prob. 13TYRCh. 4 - Prob. 14TYRCh. 4 - Prob. 15TYRCh. 4 - Prob. 16TYRCh. 4 - Prob. 17TYRCh. 4 - The cytoplasmic granule of RNA and protein that...Ch. 4 - Prob. 19TYRCh. 4 - Prob. 20TYRCh. 4 - Prob. 1BYMVCh. 4 - Prob. 2BYMVCh. 4 - Prob. 3BYMVCh. 4 - Prob. 4BYMVCh. 4 - Prob. 5BYMVCh. 4 - Prob. 6BYMVCh. 4 - Prob. 7BYMVCh. 4 - Prob. 8BYMVCh. 4 - Prob. 9BYMVCh. 4 - Prob. 10BYMVCh. 4 - Prob. 1WWTSCh. 4 - Steroids, carbohydrates, and phospholipids are...Ch. 4 - Prob. 3WWTSCh. 4 - Prob. 4WWTSCh. 4 - Prob. 5WWTSCh. 4 - The law of complementary base pairing describes...Ch. 4 - Prob. 7WWTSCh. 4 - All mutations result m the production of defective...Ch. 4 - Prob. 9WWTSCh. 4 - Prob. 10WWTSCh. 4 - Why world the supercoiled, condensed form of...Ch. 4 - Prob. 2TYCCh. 4 - Given the information in this chapter, present an...Ch. 4 - Prob. 4TYCCh. 4 - Prob. 5TYC
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- This is caused by the presence of certain cytoplasmic determinants from the expression of nuclear genes in the egg cell prior to fertilization. Delayed chromosomal inheritance Extrachromosomal Inheritance Codominance Inheritance Complete dominancearrow_forwardSuppose a man and a woman are each heterozygous carriers of a mutation causing a fatal hereditary disease not on the RUSP list. Prenatal genetic testing can identify the genotype of a fetus with regard to this disease and can identify fetuses with the disease. What do you think are the three or four most important factors this couple should consider in their decision making about having children?arrow_forwardThe mode of inheritance of the auricular hypertrichous trait in the Brown family is clearly an instance of: Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. b d recessive inheritance with the females being carriers. dominant inheritance with the males being carriers. X-linked inheritance, which is being expressed in the males since they only have one X chromosome. Y-linked inheritance, which can never be passed on to females.arrow_forward
- Why do human sex-linked recessive traits typically show up in sons more than daughters? Hint: consider the probabilities involved in the inheritance of such traits.arrow_forwardA 31 year old woman consults her physicain because she is concerned about developing breast cancer. She is currently in good health and she has never had any breast disease. Her concem arises bacause her sister has just been diagnosed as having breast cancer and her mother died of breast cancer. How can one determine if the cancer in this family is likely to be a dominantly inherited predisposition? b. What is the woman's cahnce of developing breast cancer? а.arrow_forwardDefine polygenic inheritance. List two human straits that follow this pattern of inheritance.arrow_forward
- General properties of Sex-linked Inheritance, traits is always passed from the father to son and only males are affected. *arrow_forwardA gene is termed when one copy is needed for the trait to be expressed genomic dominant recessive importantarrow_forwardExplain why Y-linked traits are passed only from fathers tosons.arrow_forward
- When does the erasure and reestablishment phase of genomicimprinting occur? Explain why it is necessary to erase an imprintand then reestablish it in order to always maintain imprinting fromthe same sex of parent.arrow_forwardVariations in Phenotype Expression Define penetrance and expressivity.arrow_forwardWhich of the following is the most likely description of the trait in the following family tree? X-linked Recessive X-linked Dominant Y-linked Autosomal Dominant Autosomal Recessivearrow_forward
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