PEARSON ETEXT FOR CAMPBELL BIOLOGY
12th Edition
ISBN: 9780135988046
Author: Urry
Publisher: PEARSON
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Chapter 44.2, Problem 2CC
Summary Introduction
To determine: The reason for the improvement in the condition of gout, if the purines are reduced in their diet of the humans as compared to the bird.
Concept introduction: The condition of the “gout” develops due to the deposition of the uric acid in the bones and the joints. This takes place due to the formation of the uric acid in the
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What is the true about renin? help me!
WHAT IF? Suppose you were studying two groupsof obese people with genetic abnormalities in theleptin pathway. In one group, the leptin levels areabnormally high; in the other group, they are abnormally low. How would each group’s leptin levels changeif they ate a low-calorie diet for an extended period?Explain.
6.
A. List all of the ionizable functional groups that are found in insulin when in aqueous solution. List which amino acid
residues have these ionizable groups and list all of the pka and pKb values (including the R groups) that are on both
polypeptide chains that make up insulin. (see the table at the end of this HW set; note that tyrosine and cysteine both have
unusual pka's, since these side groups ionize above the pKR's given to have a negative charge).
B. The isoelectric point of insulin is reported to be around 5.3-5.35. Using the method covered in class, estimate the
isoelectric point of insulin and compare your answer to the values above.
C. For a polypeptide to be soluble in an aqueous solution, is it good to be near the isoelectric point? Why or why not?
Notes: a couple of unusual R group's that ionize (cysteine and tyrosine have R groups that have pka values; histidine has a pkb). The
table at the end of this homework set (also in the lecture notes) lists the pka's and…
Chapter 44 Solutions
PEARSON ETEXT FOR CAMPBELL BIOLOGY
Ch. 44.1 - The movement of salt from the surrounding water to...Ch. 44.1 - Prob. 2CCCh. 44.1 - WHAT IF? Researchers found that a camel in the...Ch. 44.2 - What advantage does uric acid offer as a...Ch. 44.2 - Prob. 2CCCh. 44.3 - Prob. 1CCCh. 44.3 - Where and how does filtrate originate in the...Ch. 44.3 - Prob. 3CCCh. 44.4 - What do the number and length of nephrons in a...Ch. 44.4 - Many medications make the epithelium of the...
Ch. 44.4 - Prob. 3CCCh. 44.5 - How does alcohol affect regulation of water...Ch. 44.5 - Prob. 2CCCh. 44.5 - Prob. 3CCCh. 44 - Prob. 44.1CRCh. 44 - DRAW IT Construct a table summarizing the three...Ch. 44 - Prob. 44.3CRCh. 44 - Prob. 44.4CRCh. 44 - Why can only some patients with diabetes insipidus...Ch. 44 - Prob. 1TYUCh. 44 - Prob. 2TYUCh. 44 - Prob. 3TYUCh. 44 - Prob. 4TYUCh. 44 - In which of the following species should natural...Ch. 44 - Prob. 6TYUCh. 44 - Prob. 7TYUCh. 44 - Prob. 8TYUCh. 44 - SCIENTIFIC INQUIRY You are exploring kidney...Ch. 44 - Prob. 10TYUCh. 44 - SYNTHESIZE YOUR KNOWLEDGE The marine iguana...
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- 2. Describe the structure of the Insulin. Should include: The overall secondary structure of Insulin. Two specific examples of forces that are important for the tertiary structure. The quaternary structure with any additional subunits. PLEASE HELP! Thank you!arrow_forwardWA 82. Regulation of cellular metabolism by insulin requires activation of the insulin-receptor substrate protein-1 (IRS1). Some individuals who have type 2 diabetes mellitus have mutations in the IRS1 gene. Which of the following normal steps in insulin signaling is most likely to be impaired by these mutations? A) Cleavage of IRS1 by the insulin receptor B) Phosphorylation of IRS1 by the insulin receptor C) Production of inositol 1,4,5-trisphosphate by IRS1 D) Stimulation of a G protein by IRS1 E) Synthesis of diacylglycerol by IRS1arrow_forward(a) Life-threatening diarrhea is a shockingly common problemin the developing world. People with life-threatening diarrheaare often Na+-depleted, and to save their lives, replacing Na+ isessential. However, “raw” Na+ in the intestines is not absorbed.Drinking a solution of NaCl does not, therefore, replenish bodyNa+. In fact, drinking such a solution can actually worsen aperson’s situation by osmotically dehydrating the blood andother body fluids. Explain how drinking an NaCl solution couldhave this effect. (b) One of the greatest physiological discoveriesof the twentieth century was that drinking a solution of mixedglucose and NaCl can promote restoration of the body’s Na+. Withthe glucose concentration high enough in the solution, glucose“drives” the glucose–Na+ cotransporter in the apical membranesof intestinal epithelial cells, promoting Na+ uptake in sick people.Explain the concept behind this manipulation of the cotransporterfor therapeutic ends. The approach has saved millions…arrow_forward
- WHAT IF? An insulinoma is a cancerous mass ofpancreatic beta cells that secrete insulin but do notrespond to feedback mechanisms. How you wouldexpect an insulinoma to affect blood glucose levelsand liver activity?arrow_forward1. The image below shows how the human body and the endocrine system controls the level of blood sugar. O Increase in blood glucose O Decrease in blood glucose PANCREAS PANCREAS O Glucagon secretion slows O Glucagon secretion increases O Insulin secretion slows Insulin secretion increases glucagon insulin glucagon insulin LIVER MUSCLE FAT CELLS LIVER O Body cells, especially in muscle and adipose tissue, take up and use more glucose. O Cells in liver break down glycogen faster. The released glucose monomers enter blood. Cells in skeletal muscle and liver store glucose in the form of glycogen. O Decrease in blood glucose O Increase in blood glucose (a) Explain how the cells communicate with one another. (b) Using the diagram above, describe the differences between positive and negative feedback. (c) The graph above shows a day in the life of A high school student's typical day consists of eating before 8:00 am, lunch at 12:00 pm, dinner at 6:00 pm, and an evening snack around 10:00 pm.…arrow_forward8.. .arrow_forward
- The image below shows how the human body and the endocrine system controls the level of blood sugar. a) Explain how the cells communicate with one another.arrow_forwardEndocrine & Signalling 26. HO- NH2 HO- The molecule above is a hormone. Select FOUR statements that are correct with regard to this moelcule below. This is the least active form of this hormone There is another more active form of this hormone This molecule is derived from tyrosine This hormone stimulates fat metabolism Biosynthesis of this molecule requires iodine This molecule is a tryptophan metabolite This hormone targets two specific receptors This hormone stimulates fat storage This molecule is derived from cholesterol This hormone is synthesised in the adrenalsarrow_forwardVitamin D deficiencies seem to be more prevalent in the US among both adults and children. Why do you think these deficiencies are on the rise? Are there ways to naturally increase vitamin D in human systems? Is supplements of vitamin D a good idea? Why or why not. Offer some ways to maintain healthy vitamin D levels.arrow_forward
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