EBK BIOLOGY
EBK BIOLOGY
4th Edition
ISBN: 8220102797376
Author: BROOKER
Publisher: YUZU
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Chapter 44.3, Problem 2EQ

CoreSKILL » What was the hypothesis proposed by Evans in relation to PPAR-δ and obesity? How did Evans and his colleagues test this hypothesis, and what did they observe?

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.Wheeler and Mathews (J. Biol. Chem. 286:16992–16996, 2011) reported the concentrations of adenine nucleotides in rat liver mitochondria as fol- lows: ATP, 5.5 mM; ADP, 5.1 mM; AMP, 1.8 mM. (a) Calculate the adenylate energy charge within the mitochondrion [ATP] + 0.5[ADP] (adenylate energy charge [ATP] + [ADP] + [AMPJ' (b) Most measurements of adenylate energy charge in whole cells or cytosol give values close to 0.9. Speculate on reasons why it might be advantageous for mitochondria to have an ADP concentration almost as high as that of ATP. (c) succinyl-CoA + ADP + P¡ = -2.9 kJ/mol If [P;] within the mitochondrion is 0.05 M and succinate and succinyl- CoA are present at equimolar concentrations, what is the maximum succinate + ATP + CoA-SH AG°' mitochondrial concentration of CoA-SH at which the reaction can be exergonic?
norypefor he m ch ndohe R le the Problems for practc For each problem state the formula, add the data into the formula, sorve The frst problem has been done for you; this illustrates all the steps you should perform for eacn response pawenA) blirdo 1. Predict the TRC for each of the following individuals. [Write clearyn emuezs blirlo tiertt bas alnensg ari nol 20RT one jerlW () natn Bhe traing noidw 10l noijatoois der oispibni ol 1odmemeA. MALE GENOTYPE FEMALE A of active factor for each TRC= Baseline +( alleles ( active allele actve tactor for eacr TRC= Baseline +(" alleles2 active allele/ AABBCCDE TRC = 80 + (8) (12) TRC = 70 (8) (9) = 80 + 96 176 fingerprint ridges %3D 70 + 72 142 fingerprint ridges %3D = 1. If an A a Bb C cdd male mates with an A a Bb CCDD female, (a) What is the minimum number of ridge-producing genes possible for a child of this couple? (Show your work. Hint: solve gene by gene) (b) what would be the TRC for this child if it is male? (Show your work: give the…
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