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Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892

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Section
BuyFindarrow_forward

Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892
Textbook Problem

In 2003, Michelle Khan and her coworkers published their findings on a 10-year study in which they followed cervical cancer incidence and human papillomavirus (HPV) status in 20,514 women. All women who participated in the study were free of cervical cancer when the test began. Papanicolaou (Pap) tests were taken at regular intervals, and the researchers used a DNA probe hybridization test to detect the presence of specific types of HPV in the women’s cervical cells.

The results are shown as a graph of the incidence rate of cervical cancer by HPV type (Figure). Women who are HPV positive are often infected by more than one type, so the data were sorted into groups based on the women’s HPV status ranked by type: either positive for HPV16; or negative for HPV16 and positive for HPV18; or negative for HPV16/18 and positive for any other cancer-causing HPV; or negative for all cancer-causing HPV.

Chapter 45, Problem 1ITD, In 2003, Michelle Khan and her coworkers published their findings on a 10-year study in which they

FIGURE Cumulative incidence rate of cervical cancer correlated with HPV status in 20,514 women ages 16 years and older.

At 110 months into the study, what percentage of women who were not infected with any type of cancer-causing HPV had cervical cancer? What percentage of women who were infected with HPV16 also had cervical cancer?

Source: Based on M. J. Khan et al. 2005. The elevated 10-year risk of cervical neoplasia in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. Journal of the National Cancer Institute 97:1072–1079.

Summary Introduction

To analyze:

Michelle Khan and her coworkers studied cervical cancer and human papillomavirus (HPV) status in 20,514 women for 10 years and published their findings in 2003. They performed papanicolaou test at regular intervals, and the DNA probe hybridization test was performed to detect the presence of a specific type of HPV in the women’s cervical cells. No woman was infected with cervical cancer when the test began.

The percentage of women at 110 months, not infected with any type of cancer-causing HPV, had cervical cancer, and the percentage of women suffering from cervical cancer also had HPV16 infection, is to be analyzed from the graphs of their published results, given below.

The results for Michelle and her coworkers’ studies are shown in a graphical pattern below:

Biology: The Dynamic Science (MindTap Course List), Chapter 45, Problem 1ITD , additional homework tip  1

The keys for the graph are given below:

Biology: The Dynamic Science (MindTap Course List), Chapter 45, Problem 1ITD , additional homework tip  2

Introduction:

Cervical cancer is a major type of cancer found in women, mainly caused by a virus called the human papilloma virus (HPV). This virus causes cancer in the cervical cells of the uterus. There are more than 100 strains of HPV present, but only a few causes cervical cancer. The most commonly noticed cervical cancers are caused by HPV16 and HPV18.

Explanation

The percentage of women not infected with HPV, had cervical cancer at 110 months of study. The dotted orange line shows the results for the women who were tested negative for all cancer causing HPV. The graph given above shows that approximately 1% women suffer from cervical cancer at months of follow-up time...

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