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Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892

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Section
BuyFindarrow_forward

Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892
Textbook Problem

In 2003, Michelle Khan and her coworkers published their findings on a 10-year study in which they followed cervical cancer incidence and human papillomavirus (HPV) status in 20,514 women. All women who participated in the study were free of cervical cancer when the test began. Papanicolaou (Pap) tests were taken at regular intervals, and the researchers used a DNA probe hybridization test to detect the presence of specific types of HPV in the women’s cervical cells.

The results are shown as a graph of the incidence rate of cervical cancer by HPV type (Figure). Women who are HPV positive are often infected by more than one type, so the data were sorted into groups based on the women’s HPV status ranked by type: either positive for HPV16; or negative for HPV16 and positive for HPV18; or negative for HPV16/18 and positive for any other cancer-causing HPV; or negative for all cancer-causing HPV.

Chapter 45, Problem 2ITD, In 2003, Michelle Khan and her coworkers published their findings on a 10-year study in which they

FIGURE Cumulative incidence rate of cervical cancer correlated with HPV status in 20,514 women ages 16 years and older.

In which group would women infected with both HPV16 and HPV18 fall?

Source: Based on M. J. Khan et al. 2005. The elevated 10-year risk of cervical neoplasia in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. Journal of the National Cancer Institute 97:1072–1079.

Summary Introduction

To analyze:

Michelle Khan and her co-workers published their findings on a 10-year study in cervical cancer incidence and human papilloma virus status in 20,514 women in 2003. They gave a graph for their results. The group that has women infected with both HPV16 and HPV18 is to be analyzed.

Given:

The graphical representation of the study conducted by Michelle and her co-workers:

Biology: The Dynamic Science (MindTap Course List), Chapter 45, Problem 2ITD , additional homework tip  1

The key for the graph is given below.

Biology: The Dynamic Science (MindTap Course List), Chapter 45, Problem 2ITD , additional homework tip  2

Introduction:

Cervical cancer is a cancer of cervical cells in the uterus. It is mostly caused by the Human Papilloma Virus, which is sexually transmitted. Sexually active women are at a greater risk of getting infected by this virus. All the strains of HPV do not cause cervical cancer. Two strains of HPV—HPV16 and HPV18—cause cervical cancer, out of the 100 known strains.

Explanation

The group of women infected with both HPV16 and HPV18:

The blue dotted line on the graph shows the women who tested positive for HPV16 and cervical cancer, and the pink dotted line shows the women with cervical cancer and infected with HPV18, but not HPV16...

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