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Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892

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Chapter
Section
BuyFindarrow_forward

Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892
Textbook Problem

In 2003, Michelle Khan and her coworkers published their findings on a 10-year study in which they followed cervical cancer incidence and human papillomavirus (HPV) status in 20,514 women. All women who participated in the study were free of cervical cancer when the test began. Papanicolaou (Pap) tests were taken at regular intervals, and the researchers used a DNA probe hybridization test to detect the presence of specific types of HPV in the women’s cervical cells.

The results are shown as a graph of the incidence rate of cervical cancer by HPV type (Figure). Women who are HPV positive are often infected by more than one type, so the data were sorted into groups based on the women’s HPV status ranked by type: either positive for HPV16; or negative for HPV16 and positive for HPV18; or negative for HPV16/18 and positive for any other cancer-causing HPV; or negative for all cancer-causing HPV.

Chapter 45, Problem 3ITD, In 2003, Michelle Khan and her coworkers published their findings on a 10-year study in which they

FIGURE Cumulative incidence rate of cervical cancer correlated with HPV status in 20,514 women ages 16 years and older.

Is it possible to estimate from this graph the overall risk of cervical cancer associated with infection of cancer-causing HPV of any type?

Source: Based on M. J. Khan et al. 2005. The elevated 10-year risk of cervical neoplasia in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. Journal of the National Cancer Institute 97:1072–1079.

Summary Introduction

To review:

The overall risk of cervical cancer, associated with the infection of cancer-causing HPV of any type from this graph. The graph given below has the cumulative incidence rate of cervical cancer correlating with the HPV status. It is studied in 20,514 women whose ages range from 16 years to older.

Biology: The Dynamic Science (MindTap Course List), Chapter 45, Problem 3ITD

Introduction:

The cancer-causing cells are the abnormal cells that have lost the ability of controlled division. Cervical cancer occurs in the cervix of the human female. Cervical cancer is very common in women. The HPV (Human papillomavirus infection) is most commonly transmitted through infection.

Explanation

The study of cervical cancer incidence and human papillomavirus (HPV) were carried out in 20,514 women. All the women were free from cervical cancer at the initial stage when the Papanicolaou (Pap) tests began. DNA hybridization test is used to detect the specific type of HPV in cervical cancer. It is possible to estimate the risk of cervical cancer caused by cancer-causing HPV of any type. The HPV16 positive women, as shown in the above graph, are at great risk of having cervical cancer. Cervical cancer incidence, within 15 months, increased to nearly 8% and after a long time, it increases to approximately 20%...

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