Interpretation:
Why separation of the two enantiomers of
Concept introduction:
Some compounds are chiral because they contain an axis around which spatial arrangement is asymmetric, making the structure and its mirror image non-superimposable.
The two rings of
Rotation about this axis and, therefore, the equilibrium between the two enantiomers depends on the size of atoms/groups in these positions.
If the steric strain (energy barrier to rotation) is high, the equilibration between the two isomers can be slow enough to permit separation of the two isomers.
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CAREY: ORGANIC CHEMISTRY
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