Essentials of Genetics - Masteringgenetic
Essentials of Genetics - Masteringgenetic
9th Edition
ISBN: 9780134143699
Author: KLUG
Publisher: PEARSON
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Chapter 5, Problem 1PDQ

HOW DO WE KNOW?

In this chapter, we have focused on sex differentiation, sex chromosomes, and genetic mechanisms involved in sex determination. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, you should answer the following fundamental questions:

(a) How do we know that in humans the X chromosomes play no role in sex determination, while the Y chromosome causes maleness and its absence causes femaleness?

(b) How did we originally (in the late 1940s) analyze the sex ratio at conception in humans, and how has our approach to studying this issue changed in 2015?

(c) How do we know that X chromosomal inactivation of either the paternal or maternal homolog is a random event during early development in mammalian females?

(d) How do we know that Drosophila utilizes a different sex-determination mechanism than mammals, even though it has the same sex-chromosome compositions in males and females?

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Students have asked these similar questions
Butterflies have an X-Y sex-determination system that is different from that of flies or humans. Female butterflies may be either XY or X0, while butterflies with two or more X chromosomes are males. This photograph shows a tiger swallowtail gynandromorph, which is half male (left side) and half female (right side). Given that the first division of the zygote divides the embryo into the future right and left halves of the butterfly, propose a hypothesis that explains how nondisjunction during the first mitosis might have produced this unusual-looking butterfly.   Question is also in the picture.
The Amami spiny rat (Tokudaia osimensis) lacks a Y chromosome, yet scientists at Hokkaido University in Japan have reported that key sex-determining genes continue to be expressed in this species. Provide possible explanations for why male differentiation can still occur in this mammalian species despite the absence of a Y chromosome.
From 80% to 90% of the most common human chromosome abnormalities arise because the chromosomes fail to divide properly in oogenesis. Can you think of a reason why failure of chromosome division might be more common in female gametogenesis than in male gametogenesis?

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Essentials of Genetics - Masteringgenetic

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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY