BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
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Chapter 50, Problem 4S
Toll-like receptors have been found in a wide variety of organisms, including both protostomes and deuterostomes, and now in cnidarians. In addition, parts of the signaling system have been found in a wide variety of organisms as have parts of the complement system. What does this say about the evolution of innate immunity?
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Why would the discovery of TLRs alter the view that innate immunity is non-specific?
What are toll-like receptors? How do they work? What do they bind? Give an example of one and what it specifically binds. How did it help in the discovery of the innate immune system and its quick response? Contrast it to the adaptive immune system.
Some primitive organisms, such as invertebrates, have no lymphocytes and thus lack an adaptive immune system, but they have somecomponents of an innate immune system, including phagocytes andcertain protective proteins. What are some general features of innateimmunity that make it very valuable to organisms lacking more specific antibody- and cell-mediated responses? What are some disadvantages to having only an innate immune system?
Chapter 50 Solutions
BIOLOGY
Ch. 50.1 - Prob. 1LOCh. 50.1 - Prob. 2LOCh. 50.1 - Prob. 3LOCh. 50.2 - Prob. 1LOCh. 50.2 - Prob. 2LOCh. 50.2 - Prob. 3LOCh. 50.3 - Prob. 1LOCh. 50.3 - Prob. 2LOCh. 50.4 - Explain how antibody diversity is generated.Ch. 50.4 - Prob. 2LO
Ch. 50.4 - Prob. 3LOCh. 50.5 - Define autoimmune diseases.Ch. 50.5 - Prob. 2LOCh. 50.6 - Explain antigenantibody reactions in the ABO blood...Ch. 50.6 - Prob. 2LOCh. 50.6 - Prob. 3LOCh. 50.7 - Prob. 1LOCh. 50.7 - Prob. 2LOCh. 50 - How would a high level of HCG present in a urine...Ch. 50 - What would happen if an NK cell killed a virally...Ch. 50 - Prob. 2IQCh. 50 - Prob. 3IQCh. 50 - Prob. 4IQCh. 50 - Cells that target and kill body cells infected by...Ch. 50 - Structures on invading cells recognized by the...Ch. 50 - Which one of the following acts as the alarm...Ch. 50 - Prob. 4UCh. 50 - Receptors that trigger innate immune responses a....Ch. 50 - Diseases in which the persons immune system no...Ch. 50 - Suppose that a new disease is discovered that...Ch. 50 - You start a new job in a research lab. The lab...Ch. 50 - In comparing T-cell receptors and immunoglobulins...Ch. 50 - If you have type AB blood, which of the following...Ch. 50 - Suppose that you get a paper cut while studying....Ch. 50 - If you wanted to cure allergies by bioengineering...Ch. 50 - Why do we need to be repeatedly vaccinated for...Ch. 50 - Prob. 7ACh. 50 - Suppose you take a job in the marketing department...Ch. 50 - Prob. 2SCh. 50 - Prob. 3SCh. 50 - Toll-like receptors have been found in a wide...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Why is innate immunity referred to as nonspecific? Group of answer choices because it provides defense against a wide range of pathogens because it is a form of defense that functions in all human body systems because it is a form of defense found in all animal species because it provides a built-in mechanism of defense that does not require "training"arrow_forwardHelper T cells are affected by HIV, how come is this receptor key to the immune system? which line of defense are we referring to? How is it connected to the immune system and which line of defense? Hence, based on your prompt, how are cytokines linked to the defense mechanism of HIV virus? Do you know or can you explain the cascade of events dealing with PAMPS, TLRs, interferon? What do they have to do with the second line of defense?arrow_forwardWhat is the relationship and differences between receptor-mediated endocytosis and TLR in relation to innate immunity?arrow_forward
- In vertebrates, complement activation generally involves a pathogen recognition step followed by a proteolytic cascade that produces the effector proteins that function in opsonization, membrane attack, and inflammation. Which of these is likely to be the most evolutionarily primitive aspect of the complement system? Which pathway of complement initiation is likely to be the one that most recently evolved?arrow_forwardWhy is it significant that toll-like receptors (TLRs) are found on both the plasma membrane and internal cell membranes?arrow_forwardMany cells in the human body have proteins on the surface that are able to interact with the receptors of helper T cells. Explain the mechanisms and why it is that such an interaction or signal does not usually result in an autoimmune reaction?arrow_forward
- From the standpoint of defending the human body, why would it be beneficial for the cells that line the blood vessels to have TLRs on their surface?arrow_forwardWhy is innate immunity referred to as nonspecific? because it is a form of defense found in all animal species because it provides defense against a wide range of pathogens because it is a form of defense that functions in all human body systems because it provides a built-in mechanism of defense that does not require "training"arrow_forwardWhat is innate immunity? Also explain its four types of barriers.arrow_forward
- Which of the following is NOT an example of non-specific (innate) resistance mechanisms interacting directly with specific acquired immunity mechanisms? what option below is the answer? Antibodies binding to bacterial surface antigens, coating (opsonizing) the bacteria and enhancing their phagocytosis by leukocytes Macrophages and dendritic cells presenting antigens to lymphocytes None of the other four answers (All are examples of interaction between innate and acquired resistance) Antibody-dependent cell-mediated cytotoxicity Complement being activated by antigen-antibody bindingarrow_forwardAdaptive immunity includes which of the following processes? Question 2 options: A) phagocytosis B) inflammation C) production of antibody D) production of interferonarrow_forwardThe classical complement pathway is initiated by C1q binding to the surface of a pathogen. In some cases, C1q can directly bind the pathogen, for instance by recognizing proteins of bacterial cell walls, but in most cases C1q binds to IgM antibodies that are bound to the pathogen surface. How does this IgM-binding feature of C1q contribute to rapid, innate immune responses rather than to slow, adaptive responses? C1q induces B lymphocytes to begin secreting antibody within hours of pathogen exposure. Natural antibody that binds to many microbial pathogens is produced prior to pathogen exposure. C1q binds to C-reactive protein which then binds to IgM on the pathogen surface. C1q directly induces inflammation, recruiting phagocytes and antibodies from the blood into the infected tissue. C1q binds to dendritic cells in the infected tissue, inducing them to secrete inflammatory cytokines.arrow_forward
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