The article “Differences in Susceptibilities of Different Cell Lines to Bilirubin Damage” (K. Ngai, C. Yeung, and C. Leung, Journal of Paediatric Child Health, 2000:36–45) reports an investigation into the toxicity of bilirubin on several cell lines. Ten sets of human liver cells and 10 sets of mouse fibroblast cells were placed into solutions of bilirubin in albumin with a 1.4 bilirubin/albumin molar ratio for 24 hours. In the 10 sets of human liver cells, the average percentage of cells surviving was 53.9 with a standard deviation of 10.7. In the 10 sets of mouse fibroblast cells, the average percentage of cells surviving was 73.1 with a standard deviation of 9.1. Find a 98% confidence interval for the difference in survival percentages between the two cell lines.
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Statistics for Engineers and Scientists
- classify as either observational or experimental design Heart Failure. In the paper “Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure” (New England Journal of Medicine, Vol. 350, pp. 2140–2150), M. Bristow et al. reported the results of a study of methods for treating patients who had advanced heart failure due to ischemic or nonischemic cardiomyopathies. A total of 1520 patientswere randomly assigned in a 1:2:2 ratio to receive optimal pharmacologic therapy alone or in combination with either a pacemaker or a pacemaker–defibrillator combination. The patients were thenobserved until they died or were hospitalized for any cause.arrow_forwardThe article “Treadmill Exercise and Resistance Training in Patients With Peripheral Arterial Disease With and Without Intermittent Claudication. A Randomized Controlled Trial” (M. McDermott, P. Ades, et al., Journal of the American Medical Association, 2009:165–174) reported the results of a study to determine whether treadmill exercise could improve the walking ability of patients suffering from claudication, which is pain caused by insufficient blood flow to the muscles of the legs. A sample of 48 patients walked on a treadmill for six minutes every day. After six months, the mean distance walked in six minutes was 348 m, with a standard deviation of 80 m. For a control group of 46 patients who did not walk on a treadmill, the mean distance was 309 m with a standard deviation of 89 m. Find a 95% confidence interval for the difference in mean distance walked between the two groups of patients.arrow_forwardThe article “Treadmill Exercise and Resistance Training in Patients With Peripheral Arterial Disease With and Without Intermittent Claudication. A Randomized Controlled Trial” (M. McDermott, P. Ades, et al., Journal of the American Medical Association, 2009:165–174) reported the results of a study to determine whether treadmill exercise could improve the walking ability of patients suffering from claudication, which is pain caused by insufficient blood flow to the muscles of the legs. A sample of 48 patients walked on a treadmill for six minutes every day. After six months, the mean distance walked in six minutes was 348 meters, with a standard deviation of 80 m. For a control group of 46 patients who did not walk on a treadmill, the mean distance was 309 m with a standard deviation of 89 m. Can you conclude that the mean distance walked for patients using a treadmill is greater than the mean for the controls? Use the α = 0.05 level of significance.arrow_forward
- You are using a z-test to test H0: u=413 vs Ha: u<413 at the a=.1 level. What would the rejection region be for this test?arrow_forwardSuppose a researcher is interested inthe effectiveness in a new childhood exercise program implemented in a SRS of schools across a particular county. In order to test the hypothesis that the new program decreases BMI (Kg/m2), the researcher takes a SRS of children from schools where the program is employed and a SRS from schools that do not employ the program and compares the results. Assume the following table represents the SRSs of students and their BMIs. Student intervention group BMI (kg/m2) Student control group BMI (kg/m2) A 18.6 A 21.6 B 18.2 B 18.9 C 19.5 C 19.4 D 18.9 D 22.6 E 24.1 F 23.6 A) Assuming that all the necessary conditions are met (normality, independence, etc.) carry out the appropriate statistical test to determine if the new exercise program is effective. Use an alpha level of 0.05. Do not assume equal variances.B) Construct a 95% confidence interval about your estimate for the average difference in BMI between the groups.arrow_forwardDexamethasone and IQ. In the paper “Outcomes at School Age After Postnatal Dexamethasone Therapy for Lung Disease of Prematurity” (New England Journal of Medicine, Vol. 350, No. 13, pp. 1304–1313), T. Yeh et al. studied the outcomes at school age in children who had participated in a double-blind, placebo-controlled trial of early postnatal dexamethasone therapy for the prevention of chronic lung disease of prematurity. All of the infants in the study had had severe respiratory distress syndrome requiring mechanical ventilation shortly after birth. On the WeissStats site, we provide the school-age IQs of the 74 children in the control group, based on the study results. Use the technology of your choice to do the following. a. Obtain a normal probability plot, boxplot, histogram, and stemand-leaf diagram of the data. b. Based on your results from part (a), can you reasonably apply one-standard-deviation χ2-procedures to the data? Explain your reasoning. c. Overall, IQs of school-age…arrow_forward
- Is Echinacea Effective for Colds? Rhinoviruses typically cause common colds. In a test of the effectiveness of echinacea, 40 of the 45 subjects treated with echinacea developed rhi-novirus infections. In a placebo group, 88 of the 103 subjects developed rhinovirus infections (based on data from “An Evaluation of Echinacea Angustifolia in Experimental Rhinovirus Infections,” by Turner et al., New England Journal of Medicine, Vol. 353, No. 4). We want to use a 0.05 significance level to test the claim that echinacea has an effect on rhinovirus infections. a. Test the claim using a hypothesis test. b. Test the claim by constructing an appropriate confidence interval. c. Based on the results, does echinacea appear to have any effect on the infection rate?arrow_forwardBaum and Gatchel (1981, Cognitive determinants of reaction to uncontrollable events: Development of reactance andlearned helplessness. Journal of Personality and Social Psychology, 40, 1078-1089) found that students living in longcorridordorms (housing 30 to 40 residents per corridor) had greater feelings of helplessness than those living in shortcorridordorms (housing less than 20 residents per corridor). A resident director at GSU wished to test this finding tolearn whether corridor length impacted students' sense of alienation. She randomly assigned 20 students to live in aresidence hall, with 10 students in long and 10 students in short corridors for the year. At the end of the year, each2/16/21 3student completed a measure of alienation. Below are her data—does corridor length affect feelings of alienation? Use an independent samples t-test to analyze these data. Corridor LengthAlienation Scores From 20 Different StudentsLong =19,15,14,15,15,9,16,15,17,13Short =11,…arrow_forwardA heart study objective was to study heart disease among healthy volunteers.After a 10-year follow-up period involving men aged 40 to 59, there were 16 casesof coronary heart disease (CHD) among the 454 men who initially had cholesterollevels below 210 mg/100 ml (referred to as the low serum cholesterol group). Incontrast, among the 424 men whose initial cholesterol levels were at least 245mg/100 ml (referred to as the high serum cholesterol group), there were 51 cases ofCHD. With this information, Draw a 2x2 contingency table then calculate the relative risk (RR) associated with high serum cholesterol and provide an interpretation of the result.arrow_forward
- The article “Capillary Leak Syndrome in Children with C4A-Deficiency Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Double-Blind, Randomised Controlled Study” (S. Zhang, S. Wang, et al., Lancet, 2005:556–562) presents the results of a study of the effectiveness of giving blood plasma containing complement component C4A to pediatric cardiopulmonary bypass patients. Of 58 patients receiving C4A-rich plasma, the average length of hospital stay was 8.5 days and the standard deviation was 1.9 days. Of 58 patients receiving C4A-free plasma, the average length of hospital stay was 11.9 days and the standard deviation was 3.6 days. Can you conclude that the mean hospital stay is shorter for patients receiving C4A-rich plasma?arrow_forwardIn recent years, concerns have been expressed about adverse health effects from amalgam dental restorations, which include mercury. The table below shows results from a study in which some patients were treated with amalgam restorations and others were treated with composite restorations that do not contain mercury (based on data from “Neuropsychological and Renal Effects of Dental Amalgam in Children,” by Bellinger, et al., Journal of the American Medical Association, Vol. 295, No. 15). Use a 0.05 significance level to test for independence between the type of restoration and sensory disorders. Do amalgam restorations appear to affect sensory disorders? Amalgam Composite Sensory disorder 36 28 No sensory disorder 231 239arrow_forwardIn a study conducted in the Science Department of Faculty of Science, Technology and Human Development in a University; the researcher examined the influence of the drug succinylcholine on the circulation levels of androgens in the blood. Blood samples from wild, free-ranging deer were obtained via the jugular vein immediately after an intramuscular injection of succinylcholine using darts and a capture gun. Deer were bled again approximately 30 minutes after the injection and then released. The level of androgens at time of capture and 30 minutes later, measured in nanograms per milliliter (ng/ml), for 15 deers as in Table Q1. Assuming that the populations of androgen at time of injection and 30 minutes later are normally distributed:i) Find the average and standard deviation of this studyii)Determine the critical region of this problem.iii) Test at the 0.05 level of significance whether the androgen concentrations are altered after 30 minutes of restraint.arrow_forward
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