CAMPBELL BIOLOGY:CONCEPTS..W/JUNGLE>IC
15th Edition
ISBN: 9781269930741
Author: Reece
Publisher: PEARSON C
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Chapter 6, Problem 16TYK
For a short time in the 1930s, some physicians prescribed low doses of a compound called dinitrophenol (DNP) to help patients lose weight. This unsafe method was abandoned after some patients died. DNP uncouples the chemiosmotic machinery by making the inner mitochondrial membrane leaky to H+. Explain how this drug could cause profuse sweating, weight loss, and possibly death.
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A new weight loss drug, Super Fat Melter, is introduced on the market but then quickly recalled after a few patients die. As it turns out, the pill makes the lipid bilayer of the inner mitochondrial membrane leaky to H+. What impact does this have on ATP production? Explain, with reference to the type of phosphorylation affected.
When the antibiotic X is added to actively respiring mitochondria, several things happen: the yield of ATP decreases, the rate of O2 consumption increases, heat is released, and the pH gradient across the inner mitochondrial membrane increases. Does X act as an uncoupler or an inhibitor of oxidative phosphorylation? Explain the experimental observations in terms of the antibiotic’s ability to transfer K+ ions across the inner mitochondrial membrane.
Uncoupling agents are proteins spanning the inner mitochondrial membrane that allow protons to pass through the membrane and bypass the channel of ATP synthase. Describe the consequences to the proton gradient and ATP production.?
Chapter 6 Solutions
CAMPBELL BIOLOGY:CONCEPTS..W/JUNGLE>IC
Ch. 6 - Fill in the blanks in this summary map to help you...Ch. 6 - A biochemist wanted to study how various...Ch. 6 - In glycolysis, _____ is oxidized and _____ is...Ch. 6 - Which of the following is the most immediate...Ch. 6 - Which of the following is a true distinction...Ch. 6 - The poison cyanide binds to an electron carrier...Ch. 6 - In which of the following is the first molecule...Ch. 6 - Which of the three stages of cellular respiration...Ch. 6 - Compare and contrast fermentation as it occurs in...Ch. 6 - Prob. 10TYK
Ch. 6 - Prob. 11TYKCh. 6 - Prob. 12TYKCh. 6 - In the citric acid cycle, an enzyme oxidizes...Ch. 6 - ATP synthase enzymes are found in the prokaryotic...Ch. 6 - 15. SCIENTIFIC THINKING Several studies have found...Ch. 6 - For a short time in the 1930s, some physicians...Ch. 6 - Explain how the mechanism of brown fat metabolism...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Using the answer code on the right, indicate which form of energy production is being described: 1. takes place in the mitochondrial matrix 2. produces H2O as a by-product 3. results in a rich yield of ATP 4. takes place in the cytosol 5. processes acetyl-CoA 6. takes place in the mitochondrial innermembrane cristae 7. converts glucose into two pyruvate molecules 8. uses molecular oxygen 9. accomplished by the electron transport system and ATP synthase (a) glycolysis (b) citric acid cycle (c) oxidative phosphorylationarrow_forwardAn important function of the inner mitochondrial membrane is to provide a selectively permeable barrier to the movement of water soluble molecules and thus to generate different chemical environments on either side of the mem- brane. However, many of the substrates and products of oxidative phosphorylation are water soluble and must cross the inner membrane. How does this transport occur?arrow_forwardWhy does ATP production require an intact mitochondrial membrane?arrow_forward
- What would be the effect on ATP production of decreasing the pH inside the mitochondrial matrix? Explainarrow_forwardWhat are two advantages of the components of the electron transport chain being embedded in the inner mitochondrial membrane?arrow_forwardCytochrome c may associate with cardiolipin (diphosphatidylglycerol) in the inner mitochondrial membrane. What sort of intermolecular forces are likely to be involved in this association?arrow_forward
- Although the outer mitochondrial membrane is permeable to all small molecules, the inner mitochondrial membrane is essentially impermeable in the absence of specific transport proteins. Consider this information answer: If the inner mitochondrial membrane were rendered as permeable as the outer membrane, how would that affect oxidative phosphorylation? Which specific processes would stop and which remain?arrow_forwardThe inner mitochondrial membrane exhibits all of the fundamental characteristics of a typical cell membrane, but it also has several unique characteristics that are closely associated with its role in oxidative phosphorylation. What are these unique characteristics? How does each contribute to the function of the inner membrane?arrow_forwardA chemical is applied to cells that allows the free flow of protons across the mitochondrial membrane. What is the effect on the proton gradient, ATP production, heat production, and the ETC during aerobic respiration?arrow_forward
- Which directions across the mitochondria must H+, ATP, ADP, and Pi travel during active mitochondrial ATP synthesis?arrow_forwardWhich of the following statements is NOT true about the electron transport chain (ETC) and oxidative phosphorylation? A. Oxidative phosphorylation requires the enzyme complexes to be soluble in the mitochondrial matrix. B. If the proton gradient is too high, electrons will not move through the ETC. C. The movement of electrons down the ETC only happens if protons are pumped out of the mitochondrial matrix. D. Oxidative phosphorylation requires the mitochondrial intermembrane space to be more positively charged than the matrix. E. The free energy of the proton gradient can be used to create high energy bonds.arrow_forwardIn the Electron Transport Chain:(a). Upon the transfers, what is the final recipient of these electrons?(b). What is the compound obtained upon the completion of electron transportation?(c). What causes the changes in pH between the inner mitochondrial membrane during the electron transfer?arrow_forward
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