BIOLOGY-TEXT
5th Edition
ISBN: 9781260169621
Author: BROOKER
Publisher: MCG
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Chapter 6, Problem 2CQ
Summary Introduction
To determine: The mechanism and purpose of feedback inhibition in a
Introduction: Cells regulate the overproduction or underproduction of components within the system. Regulatory processes help the cells to check the unnecessary generation of substances inside the cell and also prevent the expenditure of unwanted energy in doing such activities. Feedback inhibition is one of the types of such regulatory processes.
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Many biosynthetic pathways are regulated by feedback control, where the product of a pathway turns off an enzyme that catalyzes an early step in the pathway. Usually, this control comes from an allosteric interaction. Of the types of reversible enzyme inhibition (Competitive inhibition, Noncompetitive inhibition, and Uncompetitive inhibition), what type is most likely to occur in a feedback control mechanism like this and why?
How can enzyme inhibition be used in the treatment of certain diseases? Cite examples.
Define “reciprocal inhibition” and explain its importance.
Chapter 6 Solutions
BIOLOGY-TEXT
Ch. 6.1 - Which do you think has more entropy, a NaCl...Ch. 6.1 - Prob. 2CCCh. 6.2 - Prob. 1CCCh. 6.2 - Prob. 2CCCh. 6.2 - Prob. 1CSCh. 6.2 - Prob. 1EQCh. 6.2 - Prob. 2EQCh. 6.2 - Prob. 3EQCh. 6.3 - Prob. 1CSCh. 6.3 - Prob. 2CS
Ch. 6.4 - What are advantages of protein degradation?Ch. 6 - Reactions that release free energy are a....Ch. 6 - Enzymes speed up reactions by a. providing...Ch. 6 - Prob. 3TYCh. 6 - Researchers analyzed a cell extracta mixture of...Ch. 6 - In biological systems, ATP functions by a....Ch. 6 - In a chemical reaction, NADH is converted to NAD+...Ch. 6 - Prob. 7TYCh. 6 - Prob. 8TYCh. 6 - Prob. 9TYCh. 6 - Autophagy provides a way for cells to a. degrade...Ch. 6 - Prob. 1CQCh. 6 - Prob. 2CQCh. 6 - Prob. 3CQCh. 6 - Prob. 1COQCh. 6 - Prob. 2COQ
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- Compare the mechanisms of competitive and noncompetitive inhibition of enzymes.arrow_forwardDescribe the role that compartmentation plays in the regulation of metabolic pathways. Provide several examples.arrow_forwardDifferentiate between competitive and non competitive inhibition of enzymes.arrow_forward
- List three ways to alter the rate of an enzyme-mediated reaction.arrow_forwardExplain how the following changes affect the rate of an enzyme-catalyzed reaction in the presence of an uncompetitive inhibitor: (a) increasing the substrate concentration at a constant inhibitor concentration, (b) decreasing the inhibitor concentration at a constant substrate concentration.arrow_forwardList two means by which enzyme activity is directly regulated.arrow_forward
- Define and contrast competitive and non-competitive inhibition.arrow_forwardRegarding the physical condition (characteristics of the solution/environment) in which an enzyme finds itself: sometimes enzymes are most active at a certain level and still active but to a lesser degree at a level above or below the optimal level. Describe the likely reason for the enzyme’s decrement in function at levels other than the optimal level?arrow_forwardExplain how enzymes are regulated by feedback inhibition.arrow_forward
- Define enzyme inhibition. Explain in detail the different types of inhibitions with suitable examples.arrow_forwardIf you can clearly visualize the chymotrypsin mechanism of action, you should be able to picture the structure of the transition state right after the enzyme attacks the first substrate. Think hard about what we have covered, and visualize that transition state accurately:arrow_forwardDescribe the two models that explain the behavior of allosteric enzymes. Include thelimitation or advantage of each. Give also an example of each.arrow_forward
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