Chapter 6, Problem 6.9PS

Inhibitors: Wrong Again. For each of the following false statements, change the statement to make it true.

(a) Diisopropyl fluorophosphate binds covalently to the hydroxyl group of a specific amino acid residue of the target enzyme and is therefore almost certainly an allosteric effector.

(b) The enzyme hexokinase is inhibited by its own product, glucose-6-phosphate, and is therefore an example of feedback inhibition.

(c) Glycogen synthase, like glycogen phosphorylase, is active in the phosphorylated form and inactive in the dephosphorylated form.

(d) An enzyme that is subject to allosteric activation is most likely to catalyze the final reaction in a biosynthetic pathway.

(e) If researchers claim that an enzyme is allosterically activated by compound A and allosterically inhibited by compound B, one of these claims must be wrong.