Cambell Biology 11e Vol1 For Utah Valley University Ch 1-25
11th Edition
ISBN: 9781323691519
Author: Urry
Publisher: PEARSON
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Chapter 8.5, Problem 2CC
Summary Introduction
To determine: Involvement of ATP in the feedback inhibition of a catabolic pathway.
Introduction: Feedback inhibition is a mechanism in multistep pathways that aids in ceasing the reaction when one of the substrates is over produced. The substrate that is being over produced bind to one of the enzymes of the reaction. This will in turn stop the whole cycle of reactions because each step is interdependent.
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What is true about the conformational aspects of coupling?
O The proton gradient is involved in the release of bound ATP from the synthase as a result of conformational change.
O The conformational states interconvert as a result of proton flux through the synthase.
There are two sites for substrate on the synthase and two possible conformational states: open (0) and tight-binding (T).
Dinitrophenol binds to and inhibits ATP synthase conformational changes, thus inhibiting ATP synthesis.
The Fo portion of ATP synthase acts as a rotary motor.
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Outline 4 different ways a linear pathway can be inhibited. Of the 4 described, which would be the most effective and which would be the fastest mode of inhibition?
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(a) Identify the group in pyridoxal phosphate (PLP) that covalently binds enzyme and substrate.
Hint
A
B
_H
OH
Previous
CH3
(b) Aminotransferases (transaminases) must deaminate one amino acid and add an amino group to another
amino acid during transamination. How do the two processes differ?
Map
The second part of the reaction (adding an amino group) is the reverse of the first (deamination).
The second part of the reaction takes place at a separate amino acid residue in the active site.
The first reaction involves the formation of a Schiff base, whereas the second does not.
The coenzyme PLP must be activated by an external amino group before it can catalyze the
removal of the amino group from the first amino acid.
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Chapter 8 Solutions
Cambell Biology 11e Vol1 For Utah Valley University Ch 1-25
Ch. 8.1 - MAKE CONNECTIONS How does the second law of...Ch. 8.1 - Describe the forms of energy found in an apple as...Ch. 8.1 - WHAT IF? If you place a teaspoon of sugar in the...Ch. 8.2 - Cellular respiration uses glucose and oxygen,...Ch. 8.2 - VISUAL SKILLS How would the processes of...Ch. 8.2 - WHAT IF? Some nighttime partygoers wear glow-in-...Ch. 8.3 - How does ATP typically transfer energy from an...Ch. 8.3 - Prob. 2CCCh. 8.3 - MAKE CONNECTIONS Does Figure 8.11a show passive...Ch. 8.4 - Many spontaneous reactions occur very slowly. Why...
Ch. 8.4 - Prob. 2CCCh. 8.4 - WHAT IF? Malonate is an inhibitor of the enzyme...Ch. 8.4 - Prob. 4CCCh. 8.5 - How do an activator and an inhibitor have...Ch. 8.5 - Prob. 2CCCh. 8 - Explain how the highly ordered structure of a cell...Ch. 8 - Explain the meaning of each component in the...Ch. 8 - Describe the ATP cycle: How is ATP used and...Ch. 8 - How do both activation energy barriers and enzymes...Ch. 8 - Prob. 8.5CRCh. 8 - Choose the pair of terms that correctly completes...Ch. 8 - Prob. 2TYUCh. 8 - Which of the following metabolic processes can...Ch. 8 - Prob. 4TYUCh. 8 - Some bacteria art metabolically active in hot...Ch. 8 - If an enzyme is added to a solution where its...Ch. 8 - Prob. 7TYUCh. 8 - EVOLUTION CONNECTION Some people argue that...Ch. 8 - Prob. 9TYUCh. 8 - WRITE ABOUT A THEME: ENERGY AND MATTER Life...Ch. 8 - Prob. 11TYU
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