Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 9, Problem 4NST
Summary Introduction
To explain: The phenomenon of the reduced mutation rate of mitochondrial DNA over generations.
Introduction: Mitochondria are inherited through the cytoplasm of mother in most organisms. Mitochondria carry their own DNA (deoxyribonucleic acid) and information about the genetic expression.
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Deletions in the mitochondrial DNA can result in parasitic mitochondria which do not respire but reproduce faster than normal mitochondria in a yeast cell. However, yeast cells that harvest energy only through fermentation multiply less slowly and have decreased fitness. When yeast cells containing varying populations of parasitic and normal mitochondria are grown in cultures with different cell densities over several generations, it is expected that
A. normal mitochondria will be rare in large yeast cell populations.
B. averaged across populations, yeast cells with normal mitochondria remained at intermediate levels.
C. parasitic mitochondria will be rare in large yeast cell populations.
D. parasitic mitochondria will be rare in small yeast cell populations.
All mutations in mitochondrial genes ultimately affect (whether directly or indirectly) the key function of mitochondria, which is to make ATP. Why then do mutations in different genes cause different diseases, with specific symptoms?
Explain the likely evolutionary origin of mitochondrial and chloroplast genomes. How have the sizes of the mitochondrial and chloroplast genomes changed since their origin? How has thisoccurred?
Chapter 9 Solutions
Concepts of Genetics (12th Edition)
Ch. 9 - Chlamydomonas, a eukaryoric green alga, may be...Ch. 9 - In aerobically cultured yeast, a petite mutant is...Ch. 9 - DNA in human mitochondria encodes 22 different...Ch. 9 - Prob. 4NSTCh. 9 - Why did Marcia choose mitochondrial testing to...Ch. 9 - Marcia saw an ad on television for ancestry DNA...Ch. 9 - How much importance should we place on the results...Ch. 9 - HOW DO WE KNOW? In this chapter, we focused on...Ch. 9 - Review the Chapter Concepts list on page 196. The...Ch. 9 - Streptomycin resistance in Chlamydomonas may...
Ch. 9 - A plant may have green, white, or green-and-white...Ch. 9 - In diploid yeast strains, sporulation and...Ch. 9 - Predict the results of a cross between ascospores...Ch. 9 - In Lymnaea, what results would you expect in a...Ch. 9 - In a cross of Lymnaea, the snail contributing the...Ch. 9 - In Drosophila subobscura, the presence of a...Ch. 9 - A male mouse from a true-breeding strain of...Ch. 9 - Consider the case where a mutation occurs that...Ch. 9 - What is the endosymbiotic theory, and why is this...Ch. 9 - In an earlier Problems and Discussion section (see...Ch. 9 - Mitochondrial replacement therapy (MRT) offers a...Ch. 9 - The specification of the anteriorposterior axis in...Ch. 9 - The maternal-effect mutation bicoid (bcd) is...Ch. 9 - (a) In humans the mitochondrial genome encodes a...Ch. 9 - Mutations in mitochondrial DNA appear to be...Ch. 9 - Researchers examined a family with an interesting...Ch. 9 - Payne, B. A. et al. (2013) present evidence that a...Ch. 9 - As mentioned in Section 9.3, mtDNA accumulates...Ch. 9 - Because offspring inherit the mitochondrial genome...
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- Which complex is the only complex from the respiratory pathway that has noproteins encoded by the mitochondrial chromosome?arrow_forwardTay–Sachs disease is a severe autosomal recessive genetic disease that produces deafness, blindness, seizures, and, eventually, death at 2 to 3 years of age. The disease results from a defect in the HEXA gene, which encodes hexosaminidase A. This enzyme normally degrades GM2 gangliosides. In the absence of hexosaminidase A, GM2 gangliosides accumulate in the brain. The results of molecular studies showed that the most common mutation causing Tay–Sachs disease is a 4-bp insertion that produces a downstream premature stop codon. Results of further studies have revealed that the transcription of the HEXA gene is normal in people who have Tay–Sachs disease, but the HEXA mRNA is unstable. Propose a mechanism to account for how a premature stop codon could cause mRNA instability.arrow_forwardDiscuss the different gene families present in the mitochondrial genome.arrow_forward
- Because offspring inherit the mitochondrial genome only from the mother, evolutionarily the mitochondrial genome in males encounters a dead end. The mitochondrial genome in males has no significant impact on the genetic information of future generations. Scientists have proposed that this can result in an accumulation of mutations that have a negative impact on genetic fitness of males but not females. Experiments with Drosophila support this possibility. What experimental data or evidence would you want to evaluate or consider to determine if an accumulation of mtDNA mutations negatively impacts the fitness of males of any species?arrow_forwardExplain how mutations in mitochondrial genes cause humandiseasesarrow_forwardPayne, B. A. et al. (2013) present evidence that a low level of heteroplasmic mtDNA exists in all tested healthy individuals. (a) What are two likely sources of such heteroplasmy? (b) What genetic conditions within a given mitochondrion are likely to contribute to such a variable pool of mitochondria?arrow_forward
- In humans, the glucose-6-phosphate dehydrogenase (G6PD) gene involved in sugar metabolismis X-linked. The dominant allele (G) codes for fast enzymes for normal cell functioning while the recessiveallele (g) codes for slow enzymes, which are responsible for the reduced enzymatic activity of cells.However, the presence of slow enzymes has minimal effect in the overall functioning of heterozygotes,thus normal. Recessives, however, are more prone to oxidative reactions that speed up the celldamaging process, thus weak (but not lethal). If random inactivation occurs during dosage compensation,what would be the genotypes and phenotypes of the children of a heterozygous mother and a recessivefather?arrow_forwardScientists studied gene expression and phenotypes of the YJL213W gene in yeast to determine how phosphate was transported based on two different genotypes. The PHO84 locus of the gene is a phosphate transporter and the PHO4 locus is a regulator of genes that respond to phosphate availability. Two genotypes were compared and are shown in the graph: BY (solid black line, triangles) and RM (dashed line, Xs). Which of the following statements describes the correlation between the genotype, phosphate concentration, and YJL213W expression based on the data? A - In RM genotypes, a lower PHO4 activation level led to less YJL213W expression and a lower rate of phosphate transport. B - In RM genotypes, a greater PHO4 activation level led to less YJL213W expression and a lower rate of phosphate transport. C = In BY genotypes, a lower activation level of PHO4 led to more YJL213W expression and a higher rate of phosphate transport. D - In BY genotypes a greater activation level of…arrow_forwardPlant breeders have long appreciated the phenomenoncalled hybrid vigor or heterosis, in which hybridsformed between two inbred strains have increasedvigor and crop yield relative to the two parental strains.Starting in the 1930s, seed companies exploited the cytoplasmic male sterility (CMS) phenomenon in cornthat was described in Problem 17 so that they couldcheaply produce hybrid corn seed to sell to farmers.This type of CMS is caused by mutant mitochondrialgenomes that prevent pollen formation.a. How would CMS aid seed companies in producinghybrid corn seed?Dominant Rf alleles of a nuclear gene called Restorersuppress the CMS phenotype, so that Rf-containingplants with mutant mitochondrial genomes are malefertile.b. Describe a cross generating hybrid corn seed thatwould grow into fertile (self-fertilizing) plants.(Farmers planting hybrid seed want fertile plantsbecause corn kernels result from fertilized ovules.)c. One of the historical challenges in the commercialization of hybrid…arrow_forward
- As a volunteer in a genetics lab, Professor Uhura tasked you with testing the biparental mitochondria inheritance hypothesis in Drosophila for a metabolic phenotype that they are studying. Because you just got started in the lab, the professor tells you are not allowed to use any high-end high-tech resources to perform your experiments and to collect data. The only resources you have access to are the various stocks of Drosophila available in the incubators, the resources to feed the flies and to transfer the flies from vial to vial to perform crosses, and tools to measure the metabolic phenotype of interest. Describe an experimental approach using crosses you could follow that could potentially provide you with data to support the biparental mtDNA inheritance hypothesis?arrow_forwardPlant breeders have long appreciated the phenomenon called hybrid vigor or heterosis, in which hybrids formed between two inbred strains have increased vigor and crop yield relative to the two parental strains. Starting in the 1930s, seed companies exploited the cytoplasmic male sterility (CMS) phenomenon in corn that was described in Problem 17 so that they could cheaply produce hybrid corn seed to sell to farmers. This type of CMS is caused by mutant mitochondrial genomes that prevent pollen formation. a. How would CMS aid seed companies in producing hybrid corn seed? Dominant Rf alleles of a nuclear gene called Restorer suppress the CMS phenotype, so that Rf- containing plants with mutant mitochondrial genomes are male fertile.arrow_forwardWhat was the fate of the mitochondrial genes no longer harbored by the mitochondria?arrow_forward
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY