Concept explainers
To determine:
An anesthetic drug between mepivacaine and bupivacaine which will have more of the uncharged form available at physiological
Introduction:
Mepivacaine and bupivacaine are local anesthetic drugs of the amino ester group used in epidural blocks. They contain an
The equilibrium constant
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EBK LABORATORY MANUAL FOR GENERAL, ORGA
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- Which is the stronger of the following two acids? (a) acetic acid, CH3CO2H, Ka = 1.8 105 (b) chloroacetic acid, ClCH2CO2H, pKa = 2.85arrow_forwardComplete a net ionic equation for each proton-transfer reaction using curved arrows to show the flow of electron pairs in each reaction. In addition, write Lewis structures for all starting materials and products. Label the original acid and its conjugate base; label the original base and its conjugate acid. If you are uncertain about which substance in each equation is the proton donor, refer to Table 4.1 for the relative strengths of proton acids. (a) NH3+HCl (b) CH3CH2O+HCl (c) HCO3+OH (d) CH3COO+NH4+arrow_forwardCalculate the pKa value for each of the following acids. a. Phosphoric acid (H3PO4), Ka = 7.5 103 b. Hydrofluoric acid (HF), Ka = 6.8 104 c. Hydrogen phosphate ion (HPO42), Ka = 4.2 1013 d. Propanoic acid (HC3H5O2), Ka = 1.3 105arrow_forward
- A weak base has Kb = 1.5 109. What is the value of Ka for the conjugate acid?arrow_forwardHow does the pKa of an acid change as very electronegative atoms (such as Cl) are added to the acid structure? (Does pKa increase or decrease?) How does the strength of the acid vary (increase or decrease)? Which acid below would you expect to be the stronger acid?arrow_forwardThe pKa of NaH2PO4 is 6.86. Its conjugate base is Na2HPO4. One dissolves 5.0 grams each of NaH2PO4 and Na2HPO4 in 500.0 mL of water, how many grams each of NaH2PO4 and Na2HPO4 must be dissolved in enough water to make 1.0 L of solution whose pH = 7.2? If the final concentration of NaH2PO4 is 0.1 M.arrow_forward
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