GENERAL ORGANIC+BIOL...-MOD.MASTERING..
4th Edition
ISBN: 9780135168769
Author: FROST
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 9, Problem 9.90CP
Naproxen, the active ingredient in Aleve® has the structure shown.The carboxylic acid group has a pKa of 4.2. At physiological pH of 7.4, most of this drug will be in the carboxylate, charged form.
Naproxen, pKa = 7.4
- a. Draw the carboxylate form of Naproxen.
- b. If a person lias diseased tissue with a lower pH, will more or less of the carboxylate form be present?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Calculate the pH at 25°C of a 0.89M solution of trimethylammonium chloride CH33NHCl. Note that trimethylamine CH33N is a weak base with a pKb of 4.19 .Round your answer to 1 decimal place.
A student wanted to use ascorbic acid (H2C6H6O6, a diprotic acid with pKa1 = 4.10 and pKa2 = 11.79) to find the approximate pKin for bromocresol green. She used 75 mL of 0.4 M ascorbic acid and added solid NaOH until the bromocresol green changed color. If she added 1.04 g of NaOH, what is the pKin for bromocresol green?
Using their Ka values, what is the pKb1 of
0.10 M chloroacetic acid
0.20 M carbonic acid
0.40 M citric acid
Chapter 9 Solutions
GENERAL ORGANIC+BIOL...-MOD.MASTERING..
Ch. 9 - Prob. 9.1PPCh. 9 - Indicate if each of the following statements is...Ch. 9 - Prob. 9.3PPCh. 9 - Prob. 9.4PPCh. 9 - Prob. 9.5PPCh. 9 - In each of the following equations, identify the...Ch. 9 - Prob. 9.7PPCh. 9 - Prob. 9.8PPCh. 9 - Prob. 9.9PPCh. 9 - Which of the following are strong bases? a....
Ch. 9 - Prob. 9.11PPCh. 9 - Prob. 9.12PPCh. 9 - Prob. 9.13PPCh. 9 - Prob. 9.14PPCh. 9 - Complete and balance the following neutralization...Ch. 9 - Complete and balance the following neutralization...Ch. 9 - Prob. 9.17PPCh. 9 - Complete and balance the following neutralization...Ch. 9 - Prob. 9.19PPCh. 9 - Prob. 9.20PPCh. 9 - Write an equilibrium constant expression lor the...Ch. 9 - Prob. 9.22PPCh. 9 - Prob. 9.23PPCh. 9 - Prob. 9.24PPCh. 9 - Prob. 9.25PPCh. 9 - Sulfur trioxide is produced by reacting sulfur...Ch. 9 - Prob. 9.27PPCh. 9 - Prob. 9.28PPCh. 9 - Prob. 9.29PPCh. 9 - When you exercise, energy is produced by...Ch. 9 - Using Tables 9.1 and 9.6, identity the stronger...Ch. 9 - Using Tables 9.1 and 9.6, identify the stronger...Ch. 9 - Prob. 9.33PPCh. 9 - Identify the acid and base on the reactant side of...Ch. 9 - Prob. 9.35PPCh. 9 - Prob. 9.36PPCh. 9 - Prob. 9.37PPCh. 9 - Write the formula and name of the conjugate acid...Ch. 9 - Complete the following reactions and identify the...Ch. 9 - Complete the following reactions and identify the...Ch. 9 - State if each of the following solutions is...Ch. 9 - State if each of the following solutions is...Ch. 9 - State if each of these following solutions is...Ch. 9 - Slate if each of the following solutions is...Ch. 9 - Calculate the pH of each of the solutions in...Ch. 9 - Calculate the pH of each of the solutions in...Ch. 9 - Calculate the [H3O+] for each of the following...Ch. 9 - Calculate the [H3O+J lor each of the following...Ch. 9 - Prob. 9.49PPCh. 9 - Using Table 9.8, determine the stronger acid from...Ch. 9 - Prob. 9.51PPCh. 9 - Prob. 9.52PPCh. 9 - Prob. 9.53PPCh. 9 - Prob. 9.54PPCh. 9 - Valine has the zwitterion structure shown in the...Ch. 9 - Glycine has the zwitterion structure shown in the...Ch. 9 - Prob. 9.57PPCh. 9 - Prob. 9.58PPCh. 9 - During stress or trauma, a person can start to...Ch. 9 - A person who overdoses on antacids may neutralize...Ch. 9 - Prob. 9.61APCh. 9 - Prob. 9.62APCh. 9 - Prob. 9.63APCh. 9 - What are some ingredients found in antacids? What...Ch. 9 - Prob. 9.65APCh. 9 - Prob. 9.66APCh. 9 - Prob. 9.67APCh. 9 - Prob. 9.68APCh. 9 - For the following reaction, 2HI(g)H2(g)+I2(g) a....Ch. 9 - Prob. 9.70APCh. 9 - Prob. 9.71APCh. 9 - Prob. 9.72APCh. 9 - Prob. 9.73APCh. 9 - Prob. 9.74APCh. 9 - Prob. 9.75APCh. 9 - Prob. 9.76APCh. 9 - Determine the pH for the following solutions....Ch. 9 - Determine the pi! for the following solutions....Ch. 9 - Prob. 9.79APCh. 9 - Prob. 9.80APCh. 9 - Consider the acetic-acid buffer system with acetic...Ch. 9 - Consider the lactic-acid buffer with lactic acid,...Ch. 9 - In blood plasma, pH is maintained by the carbonic...Ch. 9 - Adding a few drops o! a strong add to water will...Ch. 9 - Consider the amino acid valine shown in its...Ch. 9 - Prob. 9.86CPCh. 9 - Prob. 9.87CPCh. 9 - Prob. 9.88CPCh. 9 - Prob. 9.89CPCh. 9 - Naproxen, the active ingredient in Aleve has the...Ch. 9 - To determine the concentration of an unknown weak...Ch. 9 - Explain why the following amino acid cannot exist...Ch. 9 - Prob. 1IA.1QCh. 9 - Prob. 1IA.2QCh. 9 - Prob. 1IA.3QCh. 9 - Prob. 1IA.4QCh. 9 - Prob. 1IA.5QCh. 9 - Provide the a. conjugate base of H2S. _______ b....Ch. 9 - If the lungs fail to expel normal amounts of CO2...Ch. 9 - If the lungs expel CO2 faster than normally...Ch. 9 - Prob. 2IA.3QCh. 9 - Prob. 2IA.4QCh. 9 - Prob. 1ICCh. 9 - Prob. 2ICCh. 9 - Prob. 3IC
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Similar questions
- What fraction of iminodiacetic acid is in each of its four forms (H3AH3A H2A−H2A−, HA2−HA2−, A3−A3−) at pH 3.519? The p?apKa values for iminodiacetic acid are 1.85 (p?a1pKa1), 2.84 (p?a2pKa2) and 9.79 (p?a3pKa3).arrow_forwardWhat is the pKa of benzoic acid? What is the molar concentration of sodium benzoate (conjugate base)? What is the molar concentration of benzoic acid (weak acid)?arrow_forwardAn unknown acid was believed to be either o-nitrobenzoic acid (melting point 146-148 degrees celsius) or anthranilic acid (a.k.a. o-aminobenzoic acid) (melting point 146-148 degrees celsius). A 0.201-g sample of the unknown acid neutralized 12.4 mL of 0.098 M NaOH. What is the identity of the unknown acid? Show the calculations necessary to substantiate your selection.arrow_forward
- The pKa of benzoic acid is 4.2 Using the Henderson Hasselback equation calculate the ratio of ionized to unionized benzoic acid at a pH of 9.6. The ratio [R-COOH] : [R-COO-] = 1.arrow_forwardA monobasic acid has a neutralization equivalent of 136+/-1. This acid burns with a sooty flame and gives a negative test for nitrogen, sulfur, and halogens, and is insoluble in water and 5% NaOH. Give a possible structure for this monobasic acid.arrow_forwardHydroxychloroquine (HQ) was used to treat coronavirus. The proposed mechanism for the action of HQ is to enter into the cytoplasm of the cell and increase intracellular pH from 4.7 to 6.3 and to stop the virus from entering the cell. Looking at the structure of HQ, and the fact that the intracellular pH is increased when HQ is present, how does HQ increase the pH? Hydroxychloroquine is a weak Bronsted base. Hydroxychloroquine is a weak Arrhenius base Hydroxychloroquine is a weak Lewis acid Hydroxychloroquine is a weak Bronsted acid.arrow_forward
- Explain why a pKa is not found for the strong acid, but one will be found for the weak acid.arrow_forwardNursing Chemistry question drug name is Atorvastatin Lipitor formula C33 H35 FN2 O5 1. identify all functional groups on your structure (highlight or circle them) put the name of the functional group with it. 2.Which functional group in your drug is most acidic? What is its pka? 3.Which functional group in your drug is most basic? What is its pka (pkb)? 4.Can this compound be oxidized? Draw the product if a strong oxidizing agent is added? Draw the product if a weak oxidizing agent is added? If it cannot be oxidized explain why and show the product if a strong reducing agent is present instead. 5.If any alcohol or amine groups present-identify all their classifications. 6.List all intermolecular forces present in the functional group in yellow 7.Comparing the functional group circled in yellow, to the functional group circled in blue, which group would have a higher boiling point? Why? 8.Choose one place in molecule where you can either perform an esterification or the formation of an…arrow_forwardThe three pKa’s for phosphoric acid (H3PO4) are 2.1, 6.9, and 12.4. At what pH does [H3PO4] =[H2PO4-]? A. pH 2.1B. pH 4.6 C. pH 6.9D. pH 12.4arrow_forward
- Given that the Ka value for acetic acid is 1.8 × 10−5 and the Ka value for hypochlorousacid is 3.5 × 10−8, which is the stronger base, OCl− or C2H3O2−?arrow_forward1.95 grams of ethanolamine were dissolved in water, and the pH of the solution was adjusted with HCl until 62% of the molecules were in their protonated (conjugate acid) state. The pKa of ethanolaminium (the conjugate acid of ethanolamine) is 9.5. What is the pH of the final solution? Round your answer to one decimal place (e.g., 2.3) using standard rounding conventions for the last digit.arrow_forwardFusidic acid is a weakly acidic drug with a pKa of 4.6. It is available as the sodium salt (fusidate sodium). Calculate the percentage of fusidic acid existing in the ionized form if the injection is formulated at a pH of 6.4arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
ChemistryChemistryISBN:9781305957404Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCostePublisher:Cengage Learning
ChemistryChemistryISBN:9781259911156Author:Raymond Chang Dr., Jason Overby ProfessorPublisher:McGraw-Hill Education
Principles of Instrumental AnalysisChemistryISBN:9781305577213Author:Douglas A. Skoog, F. James Holler, Stanley R. CrouchPublisher:Cengage Learning
Organic ChemistryChemistryISBN:9780078021558Author:Janice Gorzynski Smith Dr.Publisher:McGraw-Hill Education
Chemistry: Principles and ReactionsChemistryISBN:9781305079373Author:William L. Masterton, Cecile N. HurleyPublisher:Cengage Learning
Elementary Principles of Chemical Processes, Bind...ChemistryISBN:9781118431221Author:Richard M. Felder, Ronald W. Rousseau, Lisa G. BullardPublisher:WILEY
Chemistry
Chemistry
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Cengage Learning
Chemistry
Chemistry
ISBN:9781259911156
Author:Raymond Chang Dr., Jason Overby Professor
Publisher:McGraw-Hill Education
Principles of Instrumental Analysis
Chemistry
ISBN:9781305577213
Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:Cengage Learning
Organic Chemistry
Chemistry
ISBN:9780078021558
Author:Janice Gorzynski Smith Dr.
Publisher:McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry
ISBN:9781305079373
Author:William L. Masterton, Cecile N. Hurley
Publisher:Cengage Learning
Elementary Principles of Chemical Processes, Bind...
Chemistry
ISBN:9781118431221
Author:Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:WILEY
General Chemistry | Acids & Bases; Author: Ninja Nerd;https://www.youtube.com/watch?v=AOr_5tbgfQ0;License: Standard YouTube License, CC-BY