Patho Module II Study Guide (What you need to know)

I am stuck on how to answer question 6a and 6b and 7a

The Meeting Sarah stared blankly at the blue paisley wallpaper. Her husband Mike sat by her side, bending and unbending a small paper clip. “Sarah and Michael, it’s good to meet you,” welcomed the genetic counselor, as she entered the room. “I apologize for being late, but I was just meeting with another couple. Let’s see, you’d like to have a child, but you’re concerned because of your family history of cystic fibrosis.” “Yes,” Sarah replied softly. “Mike and I met at a CF support group meeting a few years ago. He had a younger brother who died of cystic fibrosis, and I had a younger sister. We saw the painful lives they had—difficulty breathing, the constant respiratory infections. Although the treatments for CF are better now, we just don’t know if we can…” she trailed off. “I can certainly understand your concern,” the genetic counselor responded sympathetically. “That’s where I hope to help, by providing as much information and advice as I can. I’m glad that you came to see me…

Jekyll-Hyde Afflicted Spider Curse Afflicted Jekyll-Hyde/Spider Curse I O Human 1 II 1 III 4. Jekyll-Hyde disease is characterized by transformation into an unfeeling, aggressive, alter ego at night. While the "Spider Curse" is a disease that causes affected individuals to grow extra arms and extra eyes during a full moon. The genes responsible for these diseases sort independently and both traits run in one family. Based on the above pedigree answer the following questions: What is the mode of inheritance for Jekyll-Hyde disease? (Hint: look at individuals III-1 & III-3) O a. Autosomal Dominant O b. Autosomal Recessive O c. X-Linked Dominant O d. X-linked Recessive What evidence supports your hypothesis? Give at least 2 pieces of information from the pedigree that support your answer to 3a. Answer: 2. 3. 2. 2.

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Retinoblastoma: The Hits Just Keep Coming Part IV – Time to Reconvene Question Since Julie is indeed a carrier of the mutated RB1 allele and Chris is homozygous for the wild-type allele, what is the likelihood that their next child will inherit Julie’s RB1 mutation? Part V – A Different Kind of Hit Question Chris does not have an RB1 mutation, and is therefore homozygous wild-type. Julie is heterozygous for the mutation. However, Kay has inherited a different RB1 mutation than the one her mother carries. Therefore, Kay did not receive her mother’s mutant allele. Assuming that Chris really is the father, what other explanation might there be for how she got a germline mutation?

I need more explanation on this question and especially standard notation

Hi, I'm having trouble with my study guide for my upcoming genetics exam. If someone could please help with work shown and an explanation it would help so much! Thank you!! 2a. The pedigree below represents inheritance of rare condition. What pattern of inheritance is most consistent with the data? Assign alleles to all individuals to support your answer. If an allele is unknown, assign it a ? symbol. NOTE: Individuals whose phenotype or genotype cannot be determined are assumed to be unaffected and homozygous, unless otherwise indicated. 2b. In addition to the alleles you’ve indicated, describe 2 overall features of the pedigree that make it consistent with your chosen form of inheritance.  2c. Based on your mode of inheritance, what is the probability that the child of couple IV-4 x IV-5 will be affected? Show your work.  attached is the pedigree

Difference between klinefilter syndrome and turner's syndrome?

Please show explanation also.

I really need help with this queshtion please show me the work on how you got it and please explain it to me

Answer the second question? About pros and cons

Part III - Trait Analysis 1. The following pedigrees will be used to determine whether the trait is autosomal dominant or autosomal recessive. In tracing autosomal alleles, if both parents have the disorder and the offspring do not, the condition is autosomal dominant. If neither parent shows the disorder but some of their children do, the condition is autosomal recessive. A carrier is an individual who appears to be normal, but who is capable of passing on a gene for the disorder. If the characteristic is dominant, there can be no carriers because only a single gene is needed to show the disorder. Table II provides some keys for your answers. Table II - Pedigree Keys Characteristic Autosomal Dominant Autosomal Recessive Figure IV - Pedigree 1 먹어어머머 Key AA = Affected Aa Affected aa = Normal AA = Normal Aa = Carrier aa = Affected I go Q8 - Is the gene for the condition autosomal dominant or recessive? Q9 - Identify the genotype for each individual using the above table. Use A_ if…

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Part 1 Create an A3 poster that demonstrates the following genetic concepts: - The difference between continuous and discontinuous variation. - Mendel's laws of segregation and independent assortment include suitable diagrams used to illustrate these principles. - The benefits and dilemmas of twin studies in investigating variation. The poster must be available digitally and a list of citations must be included, either on the poster or attached to the assignment brief below. (Completing the poster will complete the following A.C.s 1.1, 1.4, 2.1, 2.2, 2.3, 2.4)

Please draw it out so I understand how it's suppose to be drawn

I need help answering the following question from the following article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762880/ Science and Society: In 1966, Stanley Gartler presented his findings at an international conference- 18 of the most commonly used cell lines all contained the same genetic marker, G6PD-A. This gene allele is found almost exclusively in African Americans. This was a problem because a large number of these cell lines, excluding HeLa cells, were established from Caucasian individuals. He suggested that these lines were in fact contaminated with HeLa cells, which proliferate at extreme rates and were used in labs all over the world. What would you expect was the response of those scientists using the “contaminated” cell lines? Do you think this marker is enough to establish this contamination?

QUESTION 8 Consider the following pedigree. With no other information provided, what is the most likely mode of transmission (or mode of inheritance) of the allele for the unusual trait? sex-linked recessive autosomal recessive autosomal dominant sex-linked dominant

28 Jessie and Joe are both carriers of the sickle cell trait which causes sickle cell disease when present in the recessive form. What is the likelihood that they will have 2 children, NEITHER of whom HAS the disorder NOR the trait? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a 1/4 1/16 1/8

Question 7 Listen a= albino A= Non Albino b=blond B=Dark Hair c=straight hair C=Curly Hair d-deaf D= Hearing An individual who is A/a; B/b; C/c; D/d has offspring of with someone of the same genotype. What is the probability that any offspring has the following traits Non- albino, Dark hair, Curly hair and can hear? OA) 9/256 B) 27/64 C) 81/256 D) 1/256

0000 O 1/8 1/4 1/2 QUESTION 5 A specific example of incomplete penetrance is the human bone disease osteogenesis imperfecta (OI). The majority of people with this disease have a dominant mutation in one of the two genes that produce type 1 collagen, COL1A1 or COL1A2. Based on the DNA testing of a family with 15 members, 9 members had the mutation in COL1A1. However, only 6 of them suffered from the disease. Calculate the penetrance of this mutation in this family. O a. 49% O b. 67% O c. 9% O d. 100% O e. 57% QUESTION 6 Click Save and Submit to save and submit. Click Save All Answers to save all answers. 89 MacBook Air

As a genetic counselor, you inform Susan and John that a blood test for cystic fibrosis is available. Would you recommend genetic testing for Susan and John? Explain.

Match the genetic disorder to the descriptions below: Edward Syndrome Jacob Syndrome Patau Syndrome Turner Syndrome Prader-Willi Syndrome Down Syndrome (trisomy) Klinefelter Syndrome Cri du Chat 18-Q Deletion Syndrome Translocation Down Syndrome   ________      deletion of part of the P arm of chromosome 5.  Improperly developed                         larynx causes cat-like cry until age 2.  IQ is under 20. ________      deletion of Q arm of chromosome 15.  Affected individuals have a small                         head, are retarded, and exhibit bizarre behavior.   ________      deletion of Q arm of chromosome 18.  Affected individuals have thirteen                         pairs of ribs (normal is 12 pairs) and IQ under 30. ________      extra 21st chromosome attaches to chromosome 14.  Affected individ-                         uals exhibit epicanthic folds of eyelids, simian crease in palms, and                         retardation. ________      trisomy 18.  Affected individuals…

Genetics of Neurological/Neuromuscular Disorders The genetic basis: what gene or genes are involved Environmental factors: external factors that make the underlying genetics more difficult to understand or manipulate A description of the scientific methods that are used to address the problem A discussion of social, political, and/or ethical factors that enhance or diminish our ability to deal with the genetic problem.

As a genetic counselor, you inform Susan and John that a blood test for cystic fibrosis is available. would you recommend generic testing for Susan and John?

I need explanation for the why the answer is correct? And why would the other options wrong

Question 10 please

Please help with part II of this case study (this is not a test but a homework assignment)  Please answer questions 4 and 5 See PDF here https://docplayer.net/38967044-In-sickness-and-in-health-a-trip-to-the-genetic-counselor.html Thank you!

QUESTION 10 Consider the following pedigree. With no other information provided, what is the most likely mode of transmission (or mode of inheritance) of the allele for the unusual trait? autosomal dominant sex-linked recessive autosomal recessive O sex-linked dominant

QUESTION 3. The pedigree below traces Menkes disease (MNK), an X-linked recessive disorder that affects copper levels in the body, leading to copper deficiency. MNK is caused by mutations in the copper transport gene ATP7A (abbreviated as A in the questions below), which is responsible for making a protein that is important for regulating the copper levels in the body. 1 3 4 II A. What is the genotype of individual Il-4? X^X-. XAY. e B. What type of gamete(s) and in what proportion(s) can individual II-1 make? a All Xª. b All XA. % XA, % X2. % X, ½ Y. % XA, % Y. e

Based on MS- LS3-1 Can you make a model that shows how blue eyes originated? Can you include genes, chromosomes, traits, proteins, and organisms? Can you Include a Punnett Square to show how this trait could be passed on to the next generation?  Note: can you include the drawing as question is suggested? can it be simpler for grade 8 level