PRIMARY DUODENAL EXTRASKELETAL OSTEOSARCOMA- A CASE REPORT. ABSTRACT: Extraskeletal osteosarcoma is a rare malignant soft tissue tumour, which represents about 4% of all osteosarcomas and 1% of all soft tissue sarcomas. [1, 2] We present a case of extraskeletal osteosarcoma, albeit at a hitherto undescribed site, duodenum. This case report addresses the clinicopathological features and differential diagnosis of extraskeletal osteosarcoma and the importance of clinicopathological correlation in the diagnosis and workup of such cases. Key words: extraskeletal osteosarcoma, duodenum INTRODUCTION: Extraskeletal osteosarcoma is a malignant mesenchymal neoplasm that depicts malignant osteoid, bone and/ or chondroid material. These tumours have no attachment to bone or periosteum, which has to be determined by the examination of radiological findings or observation during surgery.[1, 3] It most commonly manifests in individuals older than 50 years with the lower extremity being the most common anatomic site, followed by the upper limb and the retroperitoneum. [1, 4] We present a remarkable case of primary duodenal extra osseous osteosarcoma. CASE REPORT: The patient was a 62 year old man who was admitted with history of intermittent pain abdomen of 3 years duration. There was no history of fever, loss of appetite, loss of weight, diarrhoea or anti-tuberculosis treatment. Patient had no history of trauma or radiation therapy. Abdominal X-ray showed a heterogeneous spherical
Osteosarcoma is also called osteogenic sarcoma in medical term (“Osteosarcoma”, n.d.). This cancer usually develops in growing bones. Although it can occur at any age, it‘s most commonly found in teenagers and young adults and is slightly more common in males than females. Any bone in the body can be affected, but the most common sites are the arms or legs, particularly around the knee joint(“Osteosarcoma: An Introduction.”, 2012). This cancer is caused by benign tumors and other bone diseases, radiation exposure, genetic factors, children, adolescents, males more than females.(“Osteosarcoma: An Introduction.”, 2012)
Ewing’s Sarcoma comes in several different forms: Ewing sarcoma of bone, Extraosseous Ewing sarcoma, Peripheral Primitive Neuroectodermal tumor (pPNET), and Askin tumor. [3]The most prominent type is Ewing’s sarcoma is of the bone, having a high percentage of approximation 87
Osteosarcoma is an ancient disease that still has some mystery behind it. Osteosarcoma is a type of cancer that starts in the bones. It is also the most common type of bone cancer, and makes up 65% of all bone cancer. However, it is a very rare cancer and has fewer than 20,000 cases per year in The USA. The cells that form an osteosarcoma make bone matrix, similar to osteoblasts. However, the bone matrix of an osteosarcoma is not as strong as a bone matrix from an osteoblast, and therefore is not as strong as normal bones. The most common age group affected by osteosarcoma is children and young adults. However, osteosarcoma can occur at any age. Osteosarcoma is most commonly found in areas of the bone that grow quickly, which is why children are more likely to get this type of cancer. The most common place to find osteosarcoma is the end of long bones, especially in the knee, distal femur, and proximal tibia. The proximal humerus is typically the most common site. The treatments of
Osteosarcoma(OS) is a primary malignant tumor of bone which is characterized by the formation of osteoid tissue. Although it is the most common malignancy of long bones after multiple myeloma [2], it is a relatively rarer entity in the craniofacial region. About 6% of Oss arise in the jaws .The estimated incidence of the new cases of Jaw OS (JOS) per year is 0 .07 in 100,000. (1) The etiology of OS is unknown, but some risk factors such as a previous history of ionizing radiation, alkylating agent, retinoblastoma and benign bone lesions such as paget disease and fibro osseous dysplasia have been associated with the development of head and neck OS.(2-4) JOS occur with a peak in the third through fifth decades of life. The mean age is
MM may be detected through multiple types of tests. Lab analysis of blood may reveal the M proteins produced by myeloma cells. Another abnormal protein produced from myeloma cells called beta-2-microglobulin may be detected in the blood.3 A urine protein level test may show M proteins, which are known as Bence Jones proteins, and confirm the presence of MM.2 A bone marrow biopsy may be done to determine the number of normal and cancerous plasma cells present. An initial skeletal survey is done for diagnosis and staging through diagnostic radiography. Images will include a lateral skull x-ray, AP and lateral views of the spine and AP views of the humeri, ribs, pelvis, and femora.4 MM appears as multiple punched out osteolytic lesions scattered throughout the skeletal system.2 If seen in
Osteosarcoma most commonly develops from osteoblasts, it usually affects teenagers who are having a growth spurt. Males are more likely to have osteosarcoma than Females, and most cases of osteosarcoma involve the knee.
Both of his lung fields appear clear, with normal breath sounds, no signs of pulmonary consolidation and other abnormalities detected. His apex beat show an extra heart sound (ectopic heartbeat) which is due to the narrowing of his blood vessels that connects to the heart and to the lungs, which often occurs without a clear cause and are harmless, with no signs of murmur or split heart sounds. His abdomen is significantly distended with presence of bulging flanks pushed outwards with no signs of pain or rebound tenderness on deep palpation, and when testing for shifting dullness. He was placed in a lateral decubitus position to assess fluid shift and had a positive result. Upon percussion of Frank’s abdomen in the supine position for flank
Osteoclastomas are usually treated by removal through surgery. In some cases, the tumor may be located in an area too dangerous to perform
“Hereditary Multiple Osteochondromas (HMO) is a genetic condition in which people develop multiple benign (noncancerous) bone tumors that are covered by cartilage (called osteochondromas)” (2). HMO is estimated to affect 1 in 50,000 individuals (1). The tumors “typically form at the end of long bones and on flat bones” (1). The number, size, and location of the tumors vary between individuals (1). The tumors are not present at birth and about 96% of individuals with HMO develop multiple by the time they are 12 years old (1). Once an individual has reached skeletal maturity, the growth of tumors and the development of new tumors tends to stop (2).
Osteosarcoma, which arises from osteoid tissue in the bone. This tumor occurs most often in the knee and upper arm (1).
Tumor induced Osteomalacia is a very rare acquired neoplasm of mesenchymal origin that causes a paraneoplastic syndrome of renal phosphorus loss through the secretion of phosphatonins. The molecules are fibroblast growth factors. Whereas, the patient is a 35-year-old male who is married with two kids. Started having sever pain in his left calf about 8 years ago, which has now moved to all four of his limbs. He has no fever or weight loss of any kind since these symptoms have started. The patient has normal bowl and bladder function. The pain as gotten worse so he is seeing a neurologist to be evaluated. The 35-year-old male is bound to a wheelchair and is bed ridden do to his symptoms. He Depends on others to take care of him and all this
The patient is 69-year-old gentleman who presents to the ED complaining of rectal bleeding which has been present for about the past week. He claims past for large amount of bloody stool in the ED. His stool is guaiac is positive. There is no evidence of hemorrhoids. Work up in the ED reveals him as an abdominal CAT scan to have cholelithiasis but no acute cholecystitis. There is a cystic-appearing structure within the proximal pancreatic body and some colonic diverticular disease and he has a large right inguinal hernia with multiple nondilated loops of small bowel, nonobstructive. There is some mild elevation of his troponin therefore he was admitted acutely inpatient. Hemoglobin and hematocrit are stable and remained stable. I discussed
A 61 year old man was taken to his doctor after complaining of an altered bowel habit over the last four-five months, he suffered from constipation and diarrhoea, and recently had noted significant blood in his stools. Upon examination, he was found to be pale and the doctor thought he could feel a mass in his rectum. A blood test confirmed that he was anaemic. He was referred for urgent surgical examination and the surgeon confirmed the presence of a rectal lesion approximately 7 cm from the anal margin. No other lesions were found in the sigmoid colon or the rectum. A barium enema was performed to examine the entire length of the large bowel for other lesions. None were apparent. The tumour and adjacent bowel were removed by surgery. Histopathological
On histopathology, desmoplastic Ameloblastoma reveals small areas and thin cords of odontogenic epithelium distributed between dense, fibrous connective tissue.[7] Regions of mature lamellar bone may be seen and invasion may be also be seen.[7 This histological finding indicates the potential for local invasion and also is the reason for the diffuse appearance on radiographs. Desmoplastic Ameloblastoma is so considered more aggressive than other common variants of Ameloblastoma.[7]
The second patient, a 30 year old female, experienced pain and stiffness in her left hip/lower limb. This started in this patient at eight months old and has continued ever since. After doing a radiograph and a CT they found that there was cortical hyperostosis that involved the left iliac bone and extended into the left femur. It also involved the knee crossing the intervening joint, the left tibia, and the tarsal bones. Visually they saw osteoarthritis changes occurring with the patient's hip joint. Additionally they found bone islands located on her left femur, tibia, and patella. Bone islands benign bone tumors that are mostly encountered as an incidental and asymptomatic finding; they are suggestive of coexisting osteopoikilosis.