2. Hemoglobin mutants (Answers to this question won't be posted – discussed in Discussion.) A. For a mutant in which the T-R equilibrium is shifted toward the R state, what type of change would you expect in P50? (Would the P50 for the mutant be higher or lower than normal HbA?) Does that mean O2 affinity of mutant is higher or lower than normal? Sketch a normal HbA binding curve (sigmoid) and then sketch the curve you would expect for a mutant with T-R equilibrium shifted toward the R state.

2. Hemoglobin mutants (Answers to this question won't be posted – discussed in Discussion.) A. For a mutant in which the T-R equilibrium is shifted toward the R state, what type of change would you expect in P50? (Would the P50 for the mutant be higher or lower than normal HbA?) Does that mean O2 affinity of mutant is higher or lower than normal? Sketch a normal HbA binding curve (sigmoid) and then sketch the curve you would expect for a mutant with T-R equilibrium shifted toward the R state.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 19P

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