3) You have identified an interesting mutant in gene P. Using a Punnett square, demonstrate the cross you perform to determine if it is a dominant or recessive mutation compared to the WT gene P allele. Write the expected ratios for either scenario. 4) You have determined the mutation is dominant when compared to the WT allele. Briefly describe a technique you could use to determine if expression levels of gene P have been altered in this mutant. 5) You have determined the expression level of gene P has increased. What class/type of mutation would cause this?

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Asked Dec 12, 2019
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3) You have identified an interesting mutant in gene P. Using a Punnett square, demonstrate the cross you perform to determine if it is a dominant or recessive mutation compared to the WT gene P allele. Write the expected ratios for either scenario. 

4) You have determined the mutation is dominant when compared to the WT allele. Briefly describe a technique you could use to determine if expression levels of gene P have been altered in this mutant. 

5) You have determined the expression level of gene P has increased. What class/type of mutation would cause this? 

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Expert Answer

Step 1
  • The pure breeding lines of mutant and wild type organism must be crossed to determine if the mutation is recessive or dominant.
  • Let’s represent the wild type allele by P and the mutant allele by P’. Therefore, the genotypes of pure breeding mutant and wild type parents will be P’P’ and PP respectively. The gametes produced by mutant and wild type parents are P’ and P respectively.
  • The Punnett square showing the expected phenotype in case of dominant mutation is given in the white board.
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1) P'P' x PP ( If mutation is dominant) Gametes PP' (all mutant)

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Step 2

The Punnett square showing the expected phenotype in case ...

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2) P'P' x PP ( If mutation in recessive) Gametes PP' (all wild type) P'

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