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4) Consider three different kinds of human libraries: a genomic library, a brain cDNA library, and a liver cDNA library. I A) Suppose that all three of these libraries are sufficiently large sp as to represent all of the different human nucleotide sequences that the library could possibly include. Which of these libraries would then correspond to the largest fraction of the total human genome? B) Would you expect any of these libraries not to overlap the others at all in terms of the sequences it contains? Explain C) How do these three libraries differ in terms of the starting material for constructing the clones in the library? D) Why would you need to sequence many clones from many cDNA libraries to annotate a genome?

4) Consider three different kinds of human libraries: a genomic library, a brain cDNA library, and a liver cDNA library. I A) Suppose that all three of these libraries are sufficiently large sp as to represent all of the different human nucleotide sequences that the library could possibly include. Which of these libraries would then correspond to the largest fraction of the total human genome? B) Would you expect any of these libraries not to overlap the others at all in terms of the sequences it contains? Explain C) How do these three libraries differ in terms of the starting material for constructing the clones in the library? D) Why would you need to sequence many clones from many cDNA libraries to annotate a genome?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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ed ut References Picture v Review Drawing O Search (Alt + Q) View Help New Comment Editing ✓ Header & Footer Page Numbers TT Equation Symbol v 4) Consider three different kinds of human libraries: a genomic library, a brain cDNA library, and a liver cDNA library. # Share v I A) Suppose that all three of these libraries are sufficiently large sp as to represent all of the different human nucleotide sequences that the library could possibly include. Which of these libraries would then correspond to the largest fraction of the total human genome? B) Would you expect any of these libraries not to overlap the others at all in terms of the sequences it contains? Explain C) How do these three libraries differ in terms of the starting material for constructing the clones in the library? D) Why would you need to sequence many clones from many cDNA libraries to annotate a genome? 5) A) Is it possible to perform DNA profiling with SNPs instead of SSRS as DNA markers, but in general you would need to examine more SNP markers that the 13 SSRI used in the CODIS Text Predictions: On Editor Suggestions: Showing + 140% US C
Transcribed Image Text:ed ut References Picture v Review Drawing O Search (Alt + Q) View Help New Comment Editing ✓ Header & Footer Page Numbers TT Equation Symbol v 4) Consider three different kinds of human libraries: a genomic library, a brain cDNA library, and a liver cDNA library. # Share v I A) Suppose that all three of these libraries are sufficiently large sp as to represent all of the different human nucleotide sequences that the library could possibly include. Which of these libraries would then correspond to the largest fraction of the total human genome? B) Would you expect any of these libraries not to overlap the others at all in terms of the sequences it contains? Explain C) How do these three libraries differ in terms of the starting material for constructing the clones in the library? D) Why would you need to sequence many clones from many cDNA libraries to annotate a genome? 5) A) Is it possible to perform DNA profiling with SNPs instead of SSRS as DNA markers, but in general you would need to examine more SNP markers that the 13 SSRI used in the CODIS Text Predictions: On Editor Suggestions: Showing + 140% US C
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