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- Which of the following statements is TRUE about cholesterol biosynthesis? Group of answer choices HMG-CoA lyase catalyzes the committed step. Cholesterol is composed of 30 carbon atoms. NADH is needed to form mevalonate. Six molecules of isopentyl pyrophosphate condense to form squalene.The enzyme prenyl transferase is responsible for condensing isopentenyl pyrophosphate units during the second stage of cholesterol biogenesis. Which of the following intermediates could still form if prenyl transferase were inhibited? (A) farnesyl pyrophosphate(B) dimethylallyl pyrophosphate (C) squalene(D) geranyl pyrophosphate(E) lanosterol3-Hydroxy-3-methylglutaryl CoA is on the pathway for cholesterol biosynthesis. It is also a component of another pathway. Name the pathway. What determines which pathway 3- hydroxy-3-methylglutaryl CoA follows?
- Select the chemical events that occur between mevalonate and geranyl pyrophosphate during cholesterol synthesis: Choose ALL that apply. (A) decarboxylation to create a C5 molecule from a C6 precursor (B) condensation of (2) C5 molecules to form a C10 intermediate (C) reduction of HMG CoA(D) ATP hydrolysis (E) isomerization of isopentenyl pyrophosphate(F) condensation of a C5 molecule and a C10 molecule to form a C15 intermediate (G) formation of a tetracyclic intermediate(H) pyrophosphate (PPi) hydrolysisWhat is the role of HMG CoA reductase in cholesterol and isoprenoid synthesis?Citrate synthase mediates the transfer of what functional group to produce citrate from Oxaloacetate?
- What is the rate-limiting step in the synthesis of acetyl CoA? oxidation regeneration of lipoamide decarboxylation transfer to lipoamide transfer to CoASelect the chemical events that occur between isopentenyl pyrophosphate and lanosterol during cholesterol synthesis: Choose ALL that apply. (A) phosphorylation and decarboxylation of mevalonate(B) condensation of acetyl CoA(C) pyrophosphate (PPi) hydrolysis(D) condensation of C5 units to form C10 and C15 intermediates (E) formation of a tetracyclic intermediate (F) ATP hydrolysisWhere is the labeled carbomn found when the folliowing molecules are added to a cell carrying out palmitate synthesis. A.) biocarbonate with labelled carbon. B.) Acetyl-Coa with labeled methyl carbon
- what is the correct sequence of reactions on the given choices with regard to beta oxidation of fatty acyl-CoAIdentify a pathway for utilization of the four carbons of acetoacetate in cholesterol biosynthesis. Carry your pathway as far as the rate-determining reaction in cholesterol biosynthesis.Explain how cholesterol synthesis depends on the activity of ATPcitrate lyase.