Gap FIGURE 24.10 A multiple-sequence 50 alignment for selected members of the globin aj alpha-1 VLSP.'ADKIN VKAAWGKVGA HAGEGAEAL ERMELSFPIT KTYEPHE. DL az alpha-2 VLSP.ADKIN VKAAWGKVGA HAGEGAEAL ERMFLSFPII KIYEPHE. DL gene family in humans. 0 theta ALSA. EDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KIYFSHL. DL ( zeta SLIK.TERTI IVSMWAKIST QADIIGTETL ERLFLSHPOT KIYEPHE. DL B beta VHLTPEEKSA VIALWGKV.. NVDEVGGEAL GRLLVVYPWT QRFFESFGDL 8 delta VHLTPE EKSA VNALWG KV.. NVDAVGGEAL GRLLVVYPWT ORFFESFGDL YA gamma-A GHFTEEDKAT ITSLWG KV.. NVEDAGGEAL GRLLVVYPWT ORFFESFGDL Ye gamma-G GHFTEEDKAT ITSLWGKV.. NVEDAGGEAL GRLLVV YPWI ORFFESFGDL e epsilon VHFTA EEKAA VISLWS KM.. NVEEAGGEAL GRLLVVYPWT QRFFESFGDL Gap Gap 51 100 aj alpha-1 SHGSA... OVKGHGKKVA DALTNA VAHV DDMPNALSAL SDLHAHKLRV az alpha-2 SHGSA O theta SPGSS S zeta HPGSA. B beta STPDAVMGNP KVKAHGKKVL GAFSDGLAHL DNLKGTFAIL SELHCDKLHV 8 delta SSPDAVMGNP KVKAHGKKVL GAFSDGLAHL DNLKGTFSQL SELHCDKLHV YA gamma-A SSASAIMGNP KVKAHGKKVL TSLGDAIKHL DDLKGIFAQL SELHCDKLHV Ye gamma-G SSASAIMGNP KVKAHGKKVL TSLGDAIKHL DDLKGIFAQL SELHCDKLHV e epsilon SSPSAILGNP KVKAHGKKVL TSFGDAIKNM DNLKPAFAKL SELHCDKLHV QVKGHGKKVA DALINAVAHV DDMPNALSAL SDLHAHKLRV QVKAHGQKVA DALSLAVERL DDLPHALSAL SHLHACOLRV QLRAHGSKVV AAVGDAVKSI DDIGGALSKL SELHAYQLRV 101 148 a, alpha-1 DPVNFKLLSH CLLVILAAHL PAEFTPAVHA SLDKFLASVSs TVLTSKYR az alpha-2 DPVN FKLLSH CLLVILAAHL PAEFTPAVHA SLDKFLASVS TVLISKYR O theta DPASFQLLGH CLLVILARHL PGDFSPALQA SLDKFLSHSVI SALVSEYR ( zeta DPVNFKLLSH CLLVILAARF PADFTAEAHA AWDKFLSVVS SVLTEKYR B beta DPENFRLLGN VLVCVLAHHF GKEFIPPVQA AYQKVVAGVA NALAHKYH 8 delta DPENFR LLGN VLVCVLARNE GKEFTPOMQA AYQKVVAGVA NALAHKYH YA gamma-A DPENFRLLGN VLVCVLAIHF GKEFIPEVQA SWQKMVTAVA SALSSR YH Ye gamma-G DPENFRLLGN VLVCVLAIHF GKEFTPEVQA SWOKMVIAVA SALSSRYH e epsilon DPENFRLLGN VMV IILATHE GKEFTPEVQA AWQKLVSAVA IALAHKYH

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter28: Dna Metabolism: Replication, Recombination, And Repair

Section: Chapter Questions

Problem 10P: Homologous Recombination, Heteroduplex DNA, and Mismatch Repair Homologous recombination in E. coli...

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Related questions

Question

Take a look at the multiple-sequence alignment shown of
the globin polypeptides, focusing on amino acids 101 to 148.
A. Which of these amino acids are likely to be most important for
globin structure and function? Explain why.
B. Which are likely to be least important?

Gap
FIGURE 24.10 A multiple-sequence
50
alignment for selected members of the globin
aj alpha-1 VLSP.'ADKIN VKAAWGKVGA HAGEGAEAL ERMELSFPIT KTYEPHE. DL
az alpha-2 VLSP.ADKIN VKAAWGKVGA HAGEGAEAL ERMFLSFPII KIYEPHE. DL gene family in humans.
0 theta ALSA. EDRAL VRALWKKLGS NVGVYTTEAL ERTFLAFPAT KIYFSHL. DL
( zeta SLIK.TERTI IVSMWAKIST QADIIGTETL ERLFLSHPOT KIYEPHE. DL
B beta VHLTPEEKSA VIALWGKV.. NVDEVGGEAL GRLLVVYPWT QRFFESFGDL
8 delta VHLTPE EKSA VNALWG KV.. NVDAVGGEAL GRLLVVYPWT ORFFESFGDL
YA gamma-A GHFTEEDKAT ITSLWG KV.. NVEDAGGEAL GRLLVVYPWT ORFFESFGDL
Ye gamma-G GHFTEEDKAT ITSLWGKV.. NVEDAGGEAL GRLLVV YPWI ORFFESFGDL
e epsilon VHFTA EEKAA VISLWS KM.. NVEEAGGEAL GRLLVVYPWT QRFFESFGDL
Gap
Gap
51
100
aj alpha-1 SHGSA... OVKGHGKKVA DALTNA VAHV DDMPNALSAL SDLHAHKLRV
az alpha-2 SHGSA
O theta SPGSS
S zeta HPGSA.
B beta STPDAVMGNP KVKAHGKKVL GAFSDGLAHL DNLKGTFAIL SELHCDKLHV
8 delta SSPDAVMGNP KVKAHGKKVL GAFSDGLAHL DNLKGTFSQL SELHCDKLHV
YA gamma-A SSASAIMGNP KVKAHGKKVL TSLGDAIKHL DDLKGIFAQL SELHCDKLHV
Ye gamma-G SSASAIMGNP KVKAHGKKVL TSLGDAIKHL DDLKGIFAQL SELHCDKLHV
e epsilon SSPSAILGNP KVKAHGKKVL TSFGDAIKNM DNLKPAFAKL SELHCDKLHV
QVKGHGKKVA DALINAVAHV DDMPNALSAL SDLHAHKLRV
QVKAHGQKVA DALSLAVERL DDLPHALSAL SHLHACOLRV
QLRAHGSKVV AAVGDAVKSI DDIGGALSKL SELHAYQLRV
101
148
a, alpha-1 DPVNFKLLSH CLLVILAAHL PAEFTPAVHA SLDKFLASVSs TVLTSKYR
az alpha-2 DPVN FKLLSH CLLVILAAHL PAEFTPAVHA SLDKFLASVS TVLISKYR
O theta DPASFQLLGH CLLVILARHL PGDFSPALQA SLDKFLSHSVI SALVSEYR
( zeta DPVNFKLLSH CLLVILAARF PADFTAEAHA AWDKFLSVVS SVLTEKYR
B beta DPENFRLLGN VLVCVLAHHF GKEFIPPVQA AYQKVVAGVA NALAHKYH
8 delta DPENFR LLGN VLVCVLARNE GKEFTPOMQA AYQKVVAGVA NALAHKYH
YA gamma-A DPENFRLLGN VLVCVLAIHF GKEFIPEVQA SWQKMVTAVA SALSSR YH
Ye gamma-G DPENFRLLGN VLVCVLAIHF GKEFTPEVQA SWOKMVIAVA SALSSRYH
e epsilon DPENFRLLGN VMV IILATHE GKEFTPEVQA AWQKLVSAVA IALAHKYH

Expert Solution

Step 1

BLAST is a local alignment search tool that is used to obtain the nucleotide or protein sequences of a gene and then compared with the same protein/nucleotide sequence if different organisms to identify homology. With the help of bioinformatics application BLAST, one can retrieve any nucleotide or protein sequences from the gene database and then compare it with the genome or protein sequence of organisms of different species. The similarity in the sequence indicates homologous sequences. The homologous sequences are the means to identify common ancestry of related and non-related species and structures.

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