Good evening,Could you write me an abstract for the Dependance of Distribution Coefficient Upon pH? Even if its just the first paragraph. There is an example one ive attached below.Please help me. ❤️❤️?Thank you DownloAbstractThe partition coefficient (P) or distribution coefficient (D) is a ratio that compares thesolubilities and distribution of a solute between two immiscible solvents. It gives anindication of whether that substance is lipophilic (tends towards the non-polar phase) orhydrophilic (favours the water). If logP is less than 0, the drug partitions more intohydrophilic areas whereas if logP is greater than 0, the drug partitions more into lipophilicareas.The aim of this experiment was investigating and determining the effect of the pH of asolution on the distribution coefficient of a drug, in this case benzoic acid. In order to carryout this investigation, a pre-prepared 0.001998 mol dm stock solution of benzoic acid inethyl acetate was used to prepare standard solutions of varying concentrations whoseabsorbances were measured to produce a calibration plot. A biphasic liquid of stock solutionand pH 6.0 buffer was produced and the absorbance was then recorded and used tocalculate the distribution coefficient of benzoic acid at this pH. The process then repeatedusing pH 7.0 buffer.The oH 6.0 buffer solution had resulted in a higher logD value than the pH 7.0 buffer solution:and pH 8.0. This was because the agueous ohase at pH 7.0 was relative y more alkaline thanat pH 6.0 and so more acid molecules were ionised and so partitioned more into theaqueous ohase at oH 7.0. The outcome of this experiment wvas therefore determiningE thatbenzoic acid ismore lipophilic at pH 6.0 than at pk 7.0 and oH 8.0.Introduction

The stock solutions have a known amount of the solute dissolved in a specified volume of the…

Answered: Good evening, Could you write me an…

Good evening, Could you write me an abstract for the Dependance of Distribution Coefficient Upon pH? Even if its just the first paragraph. There is an example one ive attached below.

Principles of Instrumental Analysis

7th Edition

ISBN:9781305577213

Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Chapter33: Automated Methods Of Analysis

Section: Chapter Questions

Problem 33.8QAP

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