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RNAP can access the lacZ promoter irrespective of whether CAP-CAMP is binding the CAP o True False

RNAP can access the lacZ promoter irrespective of whether CAP-CAMP is binding the CAP o True False

Biochemistry
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter29: Transcription And The Regulation Of Gene Expression
Section: Chapter Questions
Problem 3P: Substrate Binding by RNA Polymerase RNA polymerase has t binding sites for ribonucleoside...
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RNAP can access the lacz promoter irrespective of whether CAP-CAMP is binding the CAP O True O False
Transcribed Image Text:RNAP can access the lacz promoter irrespective of whether CAP-CAMP is binding the CAP O True O False
IlvY is a LysR regulator, and it helps control transcription of a neighboring gene, ilvC. IlvY can either bend the DNA and block RNAP's access to ilvC's -35 promoter site, or it can allow access to the ilvC -35 site, thereby promoting ilvC transcription. What determines whether IlvY is repressing or activating transcription from the ilvC promoter? The presence of the co-inducer acetolactate - acetolactate binds to llvY and changes IlvY's shape such that it doesn't block the -35 of the ilvC promoter. IlvY represses ilvC transcription when the llvC protein is bound to llvY, and it activates ilvC transcription when the llvC protein is not present to bind to llvY. The presence of the co-inducer valine - when valine is present, it binds llvY and causes llvY to repress transcription from the ilvC promoter. The presence of the co-inducer acetolactate - acetolactate induces negative supercoiling at the ilvC promoter, which represses ilvC transcription.
Transcribed Image Text:IlvY is a LysR regulator, and it helps control transcription of a neighboring gene, ilvC. IlvY can either bend the DNA and block RNAP's access to ilvC's -35 promoter site, or it can allow access to the ilvC -35 site, thereby promoting ilvC transcription. What determines whether IlvY is repressing or activating transcription from the ilvC promoter? The presence of the co-inducer acetolactate - acetolactate binds to llvY and changes IlvY's shape such that it doesn't block the -35 of the ilvC promoter. IlvY represses ilvC transcription when the llvC protein is bound to llvY, and it activates ilvC transcription when the llvC protein is not present to bind to llvY. The presence of the co-inducer valine - when valine is present, it binds llvY and causes llvY to repress transcription from the ilvC promoter. The presence of the co-inducer acetolactate - acetolactate induces negative supercoiling at the ilvC promoter, which represses ilvC transcription.
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