TOPIC: Sex-linked inheritance
Glucose-6-phosphate dehydrogenase deficiency/G6PDD (g) is an X-linked recessive condition wherein the red blood cells of affected individuals undergo premature hemolysis. Fragile X syndrome (F), on the other hand, is an X-linked dominant mutation characterized by a mild to moderate intellectual disability. Amelogenesis imperfecta (AMELY) (A) is a sex-linked congenital disorder affecting the formation of the teeth enamel making affected individuals at higher risk for dental cavities and related problems. Only male offspring inherit this condition.
Jane is heterozygous for both X-linked traits like her mother. Her father is normal for both X-linked traits. James has a mother who suffers from G6PDD but not from fragile X-syndrome. His father does not exhibit any X-linked disorder but has amelogenesis imperfecta.
What are the genotypes of the following:
Jane: ________ James: _________
Jane’s mother: __________ James’ mother: ________
Jane’s father: ________ James’ father: ___________
Should Jane and James marry and have children, what is the probability of having:
a. a child with no X-linked disorder? _______
b. a daughter with Fragile X-syndrome? _______
c. a son with G6PDD? __________
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