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Mike was referred for genetic counseling because he was concerned about his extensive family history of colon cancer. That family history was highly suggestive of hereditary nonpolyposis colon cancer (HNPCC). This predisposition is inherited as an autosomal dominant trait, and those who carry the mutant allele have a 75% chance of developing colon cancer by age 65. Mike was counseled about the inheritance of this condition, the associated cancers, and the possibility of genetic testing (on an affected family member). Mike’s aunt elected to be tested for one of the genes that may be altered in this condition and discovered that she did have an altered MSH2 gene. Other family members are in the process of being tested for this mutation. Once a family member is tested for the mutant allele, is it hard for other family members to remain unaware of their own fate, even if they did not want this information? How could family dynamics help or hurt this situation?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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Section
BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 12, Problem 2CS
Textbook Problem
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Mike was referred for genetic counseling because he was concerned about his extensive family history of colon cancer. That family history was highly suggestive of hereditary nonpolyposis colon cancer (HNPCC). This predisposition is inherited as an autosomal dominant trait, and those who carry the mutant allele have a 75% chance of developing colon cancer by age 65. Mike was counseled about the inheritance of this condition, the associated cancers, and the possibility of genetic testing (on an affected family member). Mike’s aunt elected to be tested for one of the genes that may be altered in this condition and discovered that she did have an altered MSH2 gene. Other family members are in the process of being tested for this mutation.

Once a family member is tested for the mutant allele, is it hard for other family members to remain unaware of their own fate, even if they did not want this information? How could family dynamics help or hurt this situation?

Summary Introduction

To determine: Whether it is possible for the other members of the family to remain unaware of the information of cancer if they do not want to know.

Introduction: Colon cancer is defined as the uncontrolled growth of cells of the large intestine specifically colon, which is the end region of the large intestine. Most colon cancer is benign but in some cases, it can be malignant as well. The cancer property is shown by adenomatous polyps that are cancerous tumors present in the large intestine.

In the given case, Mike has a family history of nonpolyposis colon cancer. 75% of the population inheriting the mutant allele expresses it, and the gene mutation responsible for the colon cancer is present on the MSH2 gene.

Explanation of Solution

Once a family member is tested for the mutant allele, it is not compulsory that all the members of the family have inherited this allele, so the fate of the other family members is unknown...

Summary Introduction

To determine:  The way in which family dynamics can help or hurt the situation in the given case.

Introduction: The genes are responsible for the synthesis of proteins for the functioning of a cell. Mutation in the genes result in either the overexpression of the genes resulting in cancer or it can cause the production of nonfunctional proteins that control the checkpoints of the cell cycle resulting in tumor formation. The genes of cancer development are inherited by the offspring from the parents, and these genes are activated by certain factors called mutagens. The exposure to mutagens can be controlled by a person by maintaining a proper lifestyle.

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