RCA1 is a tumor suppressor gene. BRCA1* is the symbol for the non-mutant or wild-type form of the gene. art1. A woman has inherited a mutant BRCA1 allele. Her genotype is BRCA1*/BRCA1'.How many copies of the wild-type BRCA1 allele and the mutant BRCA1 allele would ou expect to find in each of her non-cancerous cells? art 2. How many copies of the wild-type BRCA1* allele and the mutant BRCA1 allele would you expect to find in each of her cancerous cells? art 3. Describe whether mutant BRCA1 acts in a recessive or dominant fashion in a cell. art 4. If you analyze this woman's eggs, how many copies of the wild-type BRCA1* allele and the mutant BRCA1° allele would you expect to find in each egg? What is the chand

RCA1 is a tumor suppressor gene. BRCA1* is the symbol for the non-mutant or wild-type form of the gene. art1. A woman has inherited a mutant BRCA1 allele. Her genotype is BRCA1/BRCA1'.How many copies of the wild-type BRCA1 allele and the mutant BRCA1 allele would ou expect to find in each of her non-cancerous cells? art 2. How many copies of the wild-type BRCA1 allele and the mutant BRCA1 allele would you expect to find in each of her cancerous cells? art 3. Describe whether mutant BRCA1 acts in a recessive or dominant fashion in a cell. art 4. If you analyze this woman's eggs, how many copies of the wild-type BRCA1* allele and the mutant BRCA1° allele would you expect to find in each egg? What is the chand

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 15QP: Which of the following mutations will result in cancer? a. homozygous recessive mutation in a...

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Which of the following mutations will result in cancer? a. homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein b. dominant mutation in a tumor-suppressor gene in which the normal protein product is overexpressed c. homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it nonfunctional d. dominant mutation in a proto-oncogene in which the normal protein product is overexpressed
Explain the difference between a proto-oncogene and a tumor suppressor gene.
What is the difference between a proto-oncogene and a tumor-suppressor gene?
Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?
Which of the following is true of tumor suppressor genes? Group of answer choices a) If this gene is overactive, it becomes an oncogene b) If one of the alleles is mutated, there is usually little effect. Two inactivating mutations are usually required for loss of function (recessive mutation). c) If one copy is lost, the gene no longer functions (dominant mutation) d) Tumor suppressors genes usually cause mitosis or cell growth e) Tumor suppressor genes decrease apoptosis
Define tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene expected to behave as a recessive gene?
Can we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb? If so, how is this possible?
Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to behave as a recessive gene?
Which of the following statements correctly describes a characteristic of tumor-suppressor gene? a) they are frequently overexpressed in cancerous cells. b) they are cancer-causing genes introduced into cells by viruses. c) they encode proteins that help prevent uncontrolled cell growth. d) they often encode proteins that stimulate the cell cycle.
What is the difference between a proto-oncogene and a tumor suppressor gene? How can mutations in these genes lead to cancer?
Which of the following accurately compares tumor suppressor genes and proto-oncogenes? A. Both tumor suppressor and proto-oncogenes prevent the spread of cancer by targeting and destroying existing cancer cells. B. A person who has both tumor suppressor and proto-oncogenes will always develop cancer. C. Proto-oncogenes code for growth factors, while tumor suppressor genes inhibit cell division of damaged cells. D. When a proto-oncogene mutates, it becomes a tumor suppressor gene.
In some cancer cells, a specific gene has been duplicated many times. Is this gene likely to be an oncogene or a tumor-suppressor gene? Explain your reasoning