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The PDH complex is a logical point of regulation in metabolism, as it links two major catabolic processes. Answer the following regarding the complex: a) Explain the advantage of E1, E2 and E3 working as a complex as opposed to separately. b) Explain the purpose of each of the three enzymes and their associated cofactors. c) NADH can inhibit the PDH complex directly or indirectly. What is the purpose of inhibition by NADH? d) Explain the differences between direct and indirect inhibition by NADH. Be sure to indicate the components involved and the mechanism of inhibition (impact on target component).

The PDH complex is a logical point of regulation in metabolism, as it links two major catabolic processes. Answer the following regarding the complex: a) Explain the advantage of E1, E2 and E3 working as a complex as opposed to separately. b) Explain the purpose of each of the three enzymes and their associated cofactors. c) NADH can inhibit the PDH complex directly or indirectly. What is the purpose of inhibition by NADH? d) Explain the differences between direct and indirect inhibition by NADH. Be sure to indicate the components involved and the mechanism of inhibition (impact on target component).

Biochemistry
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter17: Metabolism: An Overview
Section: Chapter Questions
Problem 14P
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The PDH complex is a logical point of regulation in metabolism, as it links two major catabolic processes. Answer the following regarding the complex: a) Explain the advantage of E1, E2 and E3 working as a complex as opposed to separately. b) Explain the purpose of each of the three enzymes and their associated cofactors. c) NADH can inhibit the PDH complex directly or indirectly. What is the purpose of inhibition by NADH? d) Explain the differences between direct and indirect inhibition by NADH. Be sure to indicate the components involved and the mechanism of inhibition (impact on target component).
Transcribed Image Text:The PDH complex is a logical point of regulation in metabolism, as it links two major catabolic processes. Answer the following regarding the complex: a) Explain the advantage of E1, E2 and E3 working as a complex as opposed to separately. b) Explain the purpose of each of the three enzymes and their associated cofactors. c) NADH can inhibit the PDH complex directly or indirectly. What is the purpose of inhibition by NADH? d) Explain the differences between direct and indirect inhibition by NADH. Be sure to indicate the components involved and the mechanism of inhibition (impact on target component).
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