What aspect of β cell function ultimately fails as a result of overnutrition, causing the transition from insulin resistance to fullfledged type 2 diabetes?
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What aspect of β cell function ultimately fails as a result of overnutrition, causing the transition from insulin resistance to fullfledged type 2 diabetes?
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- Why would a cause of hyperinsulinism be hypoglycemia? Don’t lower levels of blood glucose inhibit of insulin rather than produce large amounts of it to result in hyperinsulinism?Which TCA component is syphoned off to increase glucose production via gluconeogenesis when glucose consumed levels are low?describe a ketogenic diet. what are the pros and cons of such a diet. how is ketosis related to diabetes mellitus?
- Does the allosteric regulation induced by insulin activate (or repress) phosphofructokinase-1 activity?Pancreatic β cells express a receptor for fatty acids. Fatty acid binding to the protein appears to stimulate insulin secretion. Does this phenomenon make metabolic sense?Does insulin alter glucose transport by facilitated diffusion?
- In what form does the body primarily store any excess glucose?What is the effect of insulin on the committed step of glycolysis in the liver? Describe the mechanism by which insulin can affect the activity of this enzyme in the liver?Why does it make metabolic sense for the same hormone signal to stimulate glycogenolysis and inhibit glycolysis in the liver while stimulating both glycogenolysis and glycolysis in muscles?
- Would a metabolic rational for a child who has a similar diet to other children but after infections or vigorous exercise has low blood glucose levels and increased lactic acid in the blood along with potential lethargy, shakiness and irritability be type 1 diabetes? Noting that an effective treatment for them is alanine supplementation in the diet.Under FASTING state, how do the hormonal changes bring about the effect to maintain glucose homeostasis in the body through the pathways of GLYCOLYSIS and GLUCONEOGENESIS; GLYCOGENOLYSIS and GLYCOGENESIS? (Please describe the signaling pathways in detail. )Why is the cellular ratio of GSH to GSSG in cytoplasm usually high?