What enzyme catalyzes protein synthesis in bacteria? You discover a new broad-spectrum antibiotic that inhibits protein synthesis and named it Compound J. You want to determine the mechanism of action of Compound J. After treating bacteria cells with Compound J, you observe many ribosomes with long polypeptide chains bound to them. Based on this observation, make a hypothesis about which part of the ribosome Compound J is binding and how this specifically affects translation. What evidence supports that proper protein folding is essential to all domains of life? Name and describe the function/s of two specific molecules that help proteins fold in bacteria.

What enzyme catalyzes protein synthesis in bacteria? You discover a new broad-spectrum antibiotic that inhibits protein synthesis and named it Compound J. You want to determine the mechanism of action of Compound J. After treating bacteria cells with Compound J, you observe many ribosomes with long polypeptide chains bound to them. Based on this observation, make a hypothesis about which part of the ribosome Compound J is binding and how this specifically affects translation. What evidence supports that proper protein folding is essential to all domains of life? Name and describe the function/s of two specific molecules that help proteins fold in bacteria.

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter15: Genes And Proteins

Section: Chapter Questions

Problem 3VCQ: Figure 15.16 Many antibiotics inhibit bacterial protein synthesis. For example, tetracycline blocks...

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The peptidyltransferase reaction begins with the hydrolysis or breaking of the bond between the carboxyl group of the last amino acid added to the growing polypeptide and the 3' end of the tRNA in the P site. How does the ribosome get the necessary activation energy to catalyze that hydrolysis reaction?
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The antibiotic chloramphenicol binds the 50S large subunit of a ribosome as shown (the light gray area is the large subunit, while the black shape is the drug). Based on the diagram, what can you conclude about how the chloramphenicol behaves as an antibiotic?
The codon UUU in an mRNA molecule which results in phenylalanine being inserted as the protein is made. Which will be a characteristic of this codon? a. The tRNA molecule that binds to the UUU codon must have an AAA anticodon. Nde ba e2? b. UUU could code for both phenylalanine and alanine during translation. c. The aminoacyl-tRNA synthetase for phenylalanine binds only the UUU codon. d. UUU is probably only one of several codons that code for phenylalanine.
One single polypeptide chain (120 amino acid residues) is produced for protein A in prokaryotic cell. N-terminal amino acid is alanine in the chain of this protein. How many moles of ATP and GTP will be in use for this polypeptide chain synthesis? What post-translational modifications may be for this protein?
The BSA precursor protein is 607 amino acids long and has a molecular weight 69.324 kDa. If a eukaryotic ribosome can synthesize an amino acid chain at 2 amino acids/sec, how many seconds would it take for 107 ribosomes to produce 1 pg of BSA precursor?
The synthesis of a protein requires that the amino acids that constitute the growing polypeptide chain be covalently linked to the amino acid attached to the tRNA at the aminoacyl site of the ribosome. Which of the following catalyses this reaction? Options: the aminoacyl tRNA synthetase eEF2 eEF1-GTP a large ribosomal RNA the initiator tRNA met
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a- Name the figure which shows the Co-translational translocation. A or B b -list the molecules which are required for Co-translational translocation. c- Suppose you want to impair the co-translational translocation of Star protein to ER. Which strategy you choose to prevent the translocation of the Star protein to ER and maintain it in the cytoplasm. Limit your answer to two sentences. asap please.
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