Chapter 10, Problem 13P

Summary Introduction

To determine: The cleavage products of ${\text{PIP}}_{\text{2}}$ by phospholipase C.

Introduction: Phosphatidylinositol 4,5-bisphosphate ( ${\text{PIP}}_{\text{2}}$) is an essential lipid that is integral to the plasma membrane of the plant and animal cells. It works as a second messenger in a various signaling pathways and also involved in metabolic processes. ${\text{PIP}}_{\text{2}}$ is an important phosphoinositide that makes about 1% of the cell membrane. ${\text{PIP}}_{\text{2}}$ is also involved in the signaling transduction of the extracellular or intracellular components.

Summary Introduction

To compare: The DAG and IP3 with respect to their properties and solubilities in water.

Introduction: DAG and IP3 are the products of the hydrolysis of ${\text{PIP}}_{\text{2}}$ by the enzyme phospholipase C. DAG pathway is a signaling transduction pathway that is involved in the activation of enzymes. IP3 molecule is the negatively charges polar molecule. IP3 involved in the signaling transduction of chemicals such as growth factors, hormones, and neurotransmitters.

Summary Introduction

To predict: Whether either would diffuse readily through the cytosol.

Introduction: DAG and IP3 are the products of the hydrolysis of ${\text{PIP}}_{\text{2}}$ by the enzyme phospholipase C. DAG pathway is a signaling transduction pathway that is involved in the activation of enzymes. IP3 molecule is the negatively charges polar molecule. IP3 involved in the signaling transduction of chemicals such as growth factors, hormones, and neurotransmitters.