Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 10, Problem 3P
The classic demonstration that cell plasma membranes are composed of bilayers depends on the following kinds of data:
- The membrane lipids from 4.74 ×109 erythrocytes will form a monolayer of area 0.89 m2 when spread on water surface. The surface of one erythrocytes is approximately 100
- m2 in area. Show that these data can be accounted for only if the erythrocyte membrane is a bilayer.
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The inner leaflet (monolayer) of the human erythrocyte membrane consists predominantly of phosphatidylethanolamine and phosphatidylserine. The outer leaflet consists predominantly of phosphatidylcholine and sphingomyelin. Although the phospholipid components of the membrane can diffuse in the fluid bilayer, this sidedness is preserved at all times. How?
Uncharged molecules can passively pass through membranes more readily than charged molecules. Acetylsalicylic acid, better known as aspirin, has a single carboxylate group with a pKa of 3.5. Approximately what percentage of the molecule is charged in the stomach, and approximately what percentage is charged at normal blood pH at the surface of a blood vessel? Finally, per unit surface area, where would the rate of passive transfer across a membrane be highest?
A.) 1%, >99%, stomach
B.) >99%, 1%, stomach
C.) 1%, >99%, blood vessel
D.) 50%, 50%, blood vessel
E.)>99%, 1%, blood vessel
F.) 50%, 50%, stomach
One molecule of 2,3-BPG binds to one tetramer of hemoglobin in a central cavity of the hemoglobin molecule. Is the interaction between BPG and hemoglobin stronger or weaker than it would be if BPG bound to the surface of the protein instead? Explain your answer (hint: think about how these different situations affect the dielectric constant).
(Please provide clear and sufficient explanation for the question, thank you!)
Chapter 10 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 10 - Prob. 1PCh. 10 - Given these molecular components--glycerol, fatty...Ch. 10 - The classic demonstration that cell plasma...Ch. 10 - The lipid portion of a typical bilayers is about...Ch. 10 - In the following situations, what is the free...Ch. 10 - Propose an experiment that would distinguish...Ch. 10 - Prob. 7PCh. 10 - Peptide hormones (such as insulin) must bind to...Ch. 10 - Prob. 9PCh. 10 - Prob. 10P
Ch. 10 - Prob. 11PCh. 10 - Prob. 12PCh. 10 - Prob. 13PCh. 10 - Prob. 14PCh. 10 - The concentration of glucose in your circulatory...Ch. 10 - ATP is synthesized from ADP, Pi , and a proton on...Ch. 10 - The Na+/ glucose symport transports glucose from...Ch. 10 - Prob. 18PCh. 10 - Prob. 19PCh. 10 - The transport of aspirin (pKa = 3.5, structure...Ch. 10 - Prob. 21P
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