Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 10, Problem 5P
In the following situations, what is the free energy change if 1 mole of
a. In the absence of a membrane potential.
b. When the transport is opposed by a membrane potential of 70 mV.
c. In each case, will hydrolysis of 1 mole of ATP suffice to drive the transport of 1 mole of ion, assuming pH 7.4 and the following cytoplasmic concentrations: ATP =4.60 mM, Pi = 5.10 mM, ADP = 310
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In the following situations, what is the free energy change if 1 mole of Na+is transported across a membrane from a region where the concentration is1 μM to a region where it is 100 mM?(Assume T = 37 °C.) (a) In the absence of a membrane potential. (b) When the transport is opposed by a membrane potential of 70 mV. (c) In each case, will hydrolysis of 1 mole of ATP suffice to drive the transport of 1 mole of ion, assuming pH 7.4 and the following cytoplasmic concentrations: ATP = 4.60 mM, Pi = 5.10 mM, ADP = 310 μM?
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Chapter 10 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 10 - Prob. 1PCh. 10 - Given these molecular components--glycerol, fatty...Ch. 10 - The classic demonstration that cell plasma...Ch. 10 - The lipid portion of a typical bilayers is about...Ch. 10 - In the following situations, what is the free...Ch. 10 - Propose an experiment that would distinguish...Ch. 10 - Prob. 7PCh. 10 - Peptide hormones (such as insulin) must bind to...Ch. 10 - Prob. 9PCh. 10 - Prob. 10P
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- In the situations described below, what is the free energy change if 1 mole of Na+ is transported across a membrane from a region where the concentration is 48 μM to a region where it is 110 mM? (Assume T=37∘C.) In the absence of a membrane potential.arrow_forwardOuabain is a specific inhibitor of the active transport of sodium ions out of the cell and is therefore a valuable tool in studies of membrane transport mechanisms. Which of the following processes in your own body would you expect to be sensitive to inhibition by ouabain? Explain your answer in each case. a) Facilitated diffusion of glucose into a muscle cell b) Active transport of dietary phenylalanine across the intestinal mucosa c) Uptake of potassium ions by red blood cells d) Active uptake of lactose by the bacteria in your intestinearrow_forwardIn considering active transport by Na + -K + -ATPase at body temperature (37 o C), 3 Na+ are pumped out of the cell and 2 K + are pumped in for each ATP that is hydrolyzed to ADP + P i . Given that underyour experimental conditions, the DG for ATP hydrolysis is -10 kcal/mol, and that V is -60 mV, and that the pump maintains the internal Na + at 10mM, external Na + at 120 mM, internal K + at 120 mM and external K + at 8mM, what is the efficiency of the pump (i.e., what fraction of the energy available from ATP hydrolysis is required to drive transport at the provided levels)?arrow_forward
- A.What is the Result of the sodium potassium ATPase activity in the cell? B.What mechanism does the sodium potassium ATPase use to achieve this result? C. Why is the above-mentioned change in affinity critical for the sodium potassium ATPase to perform its function?arrow_forwardCalculate the energy required for, or released in, a transport of 20 Na+ ions and of 100 molecules of glucose into a biological cell at 37 oC if the membrane potential is –50 mV (negative inside the cell), the concentrations of Na+ and glucose inside the cell are 0.001mol L-1 and 0.01mol L-1 consequently and the concentrations of Na+ and glucose outside of the cell are 0.1mol L-1 and 0.001mol L-1 consequently.arrow_forwardCalculate the equilibrium membrane potentials to be expected across a membrane at 37 ∘C, with a NaCl concentration of 0.50M on the "right side" and 0.08 M on the "left side", given the following conditions. In each case, state which side is (+) and which is (−). Membrane permeable only to Cl−.arrow_forward
- Glucose can be transported into cells with a glucose/sodium symporter. If the extracellular concentration of sodium is always in excess to that of glucose, which of these manipulations would MOST increase the rate of glucose transport into a cell? A. increase in the extracellular concentration of sodium B. increase in the intracellular concentration of sodium C. increase in the extracellular concentration of glucose D. increase in the intracellular concentration of glucose I believe the correct answer is A because once the extracellular concentration of Na is increase, this will drive the Na-glucose symporter to pump Na down its gradient, which will "pull" the glucose into the cell against its gradient. However, the previous Bartleby answer was B. Please explain why A is not right. Thanks!arrow_forwardYou have a semi permeable membrane with a membrane potential of -90mV. You also have two ions that are both permeable to the membrane, Na and Cl. Na has a concentration of 10mM inside the membrane and 120mM outside the membrane. Cl has a concentration of 1.5mM inside the membrane and 77.5mM outside the membrane. Use the nernst equation to calculate the electrochemical equilibrium of both ions, and show in which direction the netflux would be for each ion.arrow_forwardUniporters and ion channels support facilitated transport across cellular membranes. Although both are examples of facilitated transport, the rates of ion movement via an ion channel are roughly 104- to 105-fold faster than the rates of molecule movement via a uniporter. What key mechanistic difference results in this large difference in transport rate? What contribution to free energy (ΔG) determines the direction of transport?arrow_forward
- The equilibrium potential for a given ion (Eion) is a theoretical value. For a given concentration gradient of an ion, the equilibrium potential is the charge inside the cell required to hold an ion at that concentration. That is, it is the charge required to perfectly oppose the drive of the ion to move down its concentration gradient. So, if the concentration of Nat is higher outside the cell than inside, its equilibrium potential (ENa) must be I and if we add more sodium to the extracellular fluid, then ENa will II.arrow_forwardConsider the transport of K+ ions from a surrounding fluid (where [K + ] = 30 mM) into a cell (where [K + ] = 420 mM) where the membrane electrical potential is -0.15 V. Is this process favorable?arrow_forwardBelow find the structures for ibogaine and cocaine. Ibogaine and cocaine inhibit the dopamine active transporter (DAT). This transporter is a secondary active transporter, and depends on the primary active transporter Na+/K+ ATPase. Ibogaine had a Kι = 2 μM, and cocaine a Kι = 0.64 μM respectively. (a) Define secondary active transport. (b) Is ibogaine an effective treatment for cocaine based on DAT binding?arrow_forward
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