Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 10, Problem 15P
The concentration of glucose in your circulatory system is maintained near 5.0 mM by the actions of the pancreatic hormones glucagon and insulin. Glucose is imported into cells by protein transporters that are highly specific for binding glucose. Inside the liver cells the imported glucose is rapidly phosphorylated to give glucose-6-phosphate (G-6-P). This is an ATP-dependent process that
consumes 1 mol ATP per mol of glucose.
a. The process of phosphorylating the glucose after it has been transported into the cell is considered a form of active transport —called "transport by modification” though ATP is not bound by the transporter protein, nor is ATP hydrolysis directly involved in the movement of glucose across the membrane. Explain the
b. Given
ATP = 4.7 mM; ADP = 0.15 mM; Pi = 6.1 mM, calculate the theoretical maximum concentration of G-6-P
inside a liver cell at 37 oC, pH = 7.2 when the glucose concentration outside the cell (i.e., [glucose]outside) is 5.0 mM:
ATP + glucoseinside→ADP + glucose-6-phosphate + H+
For
ATP + H2O →ADP + Pi + H+ ΔGo’ = -32.2 kJ/mol and for
G-6-P + H2O →Glucose + Pi ΔGo’ = -13.8 kJ / mol
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The Nutrition Facts label on most food products shows % daily values based on a food energy
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a) Assuming that the efficiency of converting food energy to ATP is 50%, calculate the mass of ATP (in
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The actions of cardiac glycoside drugs are not confined exclusively to heart tissue. How would ingestion of a cardiac glycoside affect uptake of glucose in the intestine? Refer to actions of the cardiac glycoside on the system in the image above in your answer. 5. Calculate the free energy change associated with moving glucose into the cell. The experimental conditions are as follows: 37 °C, 5 mM extracellular glucose, 0.4 mM intracellular glucose. Show all work.
if an 8.4-oz (250 mL) energy drink can has 27 grams of sugar, calculate the moles of ATP produced in the body when 1 oz of the drink is consumed assuming all the sugars in 1 oz of the drink are composed of only glucose.
Chapter 10 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 10 - Prob. 1PCh. 10 - Given these molecular components--glycerol, fatty...Ch. 10 - The classic demonstration that cell plasma...Ch. 10 - The lipid portion of a typical bilayers is about...Ch. 10 - In the following situations, what is the free...Ch. 10 - Propose an experiment that would distinguish...Ch. 10 - Prob. 7PCh. 10 - Peptide hormones (such as insulin) must bind to...Ch. 10 - Prob. 9PCh. 10 - Prob. 10P
Ch. 10 - Prob. 11PCh. 10 - Prob. 12PCh. 10 - Prob. 13PCh. 10 - Prob. 14PCh. 10 - The concentration of glucose in your circulatory...Ch. 10 - ATP is synthesized from ADP, Pi , and a proton on...Ch. 10 - The Na+/ glucose symport transports glucose from...Ch. 10 - Prob. 18PCh. 10 - Prob. 19PCh. 10 - The transport of aspirin (pKa = 3.5, structure...Ch. 10 - Prob. 21P
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