Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 10.3, Problem 2TQ
Summary Introduction
To review:
The growth of fur mutant on succinate based on the regulatory circuit of small RNA (ribonucleic acid) RyhB, the iron regulatory protein Fur, and succinate dehydrogenase.
Introduction:
The small regulatory RNAs are the noncoding molecules of RNA that play an important role in cellular processes like activation and inhibition. These are composed of several stem loop structures. These RNAs play a crucial role in the regulation of genes through various mechanisms.
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Chapter 10 Solutions
Microbiology: An Evolving Science (Fourth Edition)
Ch. 10.1 - Prob. 1TQCh. 10.2 - Prob. 1TQCh. 10.2 - Prob. 2TQCh. 10.2 - Prob. 3TQCh. 10.2 - Prob. 4TQCh. 10.2 - Prob. 5TQCh. 10.3 - Prob. 1TQCh. 10.3 - Prob. 2TQCh. 10.4 - Prob. 1TQCh. 10.5 - Prob. 1TQ
Ch. 10.5 - Prob. 2TQCh. 10.6 - Prob. 1TQCh. 10 - Prob. 1RQCh. 10 - Prob. 2RQCh. 10 - Prob. 3RQCh. 10 - Prob. 4RQCh. 10 - Prob. 5RQCh. 10 - Prob. 6RQCh. 10 - Prob. 7RQCh. 10 - Prob. 8RQCh. 10 - Prob. 9RQCh. 10 - Prob. 10RQCh. 10 - Prob. 11RQCh. 10 - Prob. 12RQCh. 10 - Prob. 13RQCh. 10 - Prob. 14RQCh. 10 - Prob. 1TQCh. 10 - Prob. 2TQCh. 10 - Prob. 3TQCh. 10 - Prob. 4TQ
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- Describe the positive outcome of mutation to the regulatory DNA for expression of the lactase gene. Why was this mutation important to the human population?arrow_forwardHow is the activation of the GAL1 gene prevented in thepresence of galactose and glucose?arrow_forwardWhat would be the effect on an organism’s ability to use glucose as an energy source if a mutation inactivated glucose 6-phosphatase in the liver?arrow_forward
- In a line of human cells grown in culture, a geneticist isolates a temperature-sensitive mutation at a locus that encodes an acetyltransferase enzyme; at temperatures above 38°C, the mutant cells produce a nonfunctional form of the enzyme. What would be the most likely effect of this mutation if the cells were grown at 40°C?arrow_forwardList and explain two ways that this transcription factor (HIF-1α) relates to glucose metabolism.arrow_forwardExamine the table below for the pathway with precursors / products A, B, C, D, and E and mutant enzymes 1, 2, 3, and 4. Use the information given to draw the pathway. (+ indicates growth, 0 indicates no growth) A B C D E 1 + 0 0 0 + 2 + + 0 0 + 3 + + 0 + + 4 0 0 0 0 + Later a new mutation (5) is found that fails to complement mutant 2. Between what two compounds on the pathway is this new mutant located?arrow_forward
- A mutation occurred on the lacI (repressor) gene resulting in a constant production of beta-galactosidase and permease, even in the absence of lactose. Provide an explanation for the effect of this mutation on the repressor protein moleculearrow_forwardBriefly explain how heme regulates the expression of globin genes in cells that synthesize hemoglobin.arrow_forwardWhich option is true when considering the regulation of cAMP and the Lac operon. If bacteria are in a medium containing low glucose, but suddenly glucose concentration in the medium increases by ten times, then we expect that cAMP...... a) Will increase inside the cell. b) Will not increase inside the cell.arrow_forward
- The intermediates A, B, C, D, E, and F all occur inthe same biochemical pathway. G is the product of thepathway, and mutants 1 through 7 are all G−, meaningthat they cannot produce substance G. The followingtable shows which intermediates will promote growthin each of the mutants. Arrange the intermediates inorder of their occurrence in the pathway, and indicatethe step in the pathway at which each mutant strain isblocked. A + in the table indicates that the strain willgrow if given that substance, an O means lack of growth.SupplementsMutant A B C D E F G1 + + + + + O +2 O O O O O O +3 O + + O + O +4 O + O O + O +5 + + + O + O +6 + + + + + + +7 O O O O + O +arrow_forwardWhat would be the effect of a drug that altered the structure of allolactose so that it was unable to bind to the regulator protein?arrow_forwardSuccinate dehydrogenase is an iron-containing protein, and its expression is induced by high iron levels. This enzyme is necessary for growth on succinate. Would a fur mutant be able to grow on succinate?arrow_forward
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