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A chemical called dioxin is produced as a by-product of certain chemical manufacturing processes. Trace amounts of this substance were present in Agent Orange, a defoliant sprayed on vegetation during the Vietnam War. There has been a continuing controversy over its effects on soldiers exposed to Agent Orange during the war. Animal tests have suggested that dioxin can cause cancer, liver and thymus damage, immune system suppression, and birth defects; at high dosage it can be lethal. But such animal tests are inconclusive; a hamster is not affected by a dose that can kill a much larger guinea pig, for example. Researchers have discovered that dioxin enters a cell and binds to a protein that in turn attaches to the cell’s DNA. How might this mechanism help explain the variety of dioxin’s effects on different body systems and in different animals? How might you determine whether a particular individual became ill as a result of exposure to dioxin? Do you think this information is relevant in the lawsuits of soldiers suing over exposure to Agent Orange? Why or why not?
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Campbell Essential Biology with Physiology (5th Edition)
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