To analyze:
a) Considering random segregation of the chromosome, determine the genotype and proportion of the sperm produced by the trisomic male fruit fly with genotype
b) Determine the expected ratio of the eyeless to normal eyed flies produced by the union of the sperm with the egg having genotype eyey producing an eyeless
Introduction:
The segregation of the chromosome during cell division is an important phenomenon. If the chromosome fails to segregate properly, it is called non-disjunction, and it could have resulted in the daughter cell with one extra chromosome (
The cell with improper distribution of the chromosomes may reduce their survival rate as compared to the normal cell. In the germ cells, non-disjunction results in the formation of gametes with extra or missing chromosomes which leads to the production of aneuploidy gametes. Germ cells, egg or sperms, are haploid cells, containing a single pair of chromosome. The condition of the presence of extra chromosome (
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GENETIC ANALYSIS: AN INTEG. APP. W/MAS
- In Drosophila, a cross (cross 1) was made between twomutant flies, one homozygous for the recessive mutationbent wing (b) and the other homozygous for the recessivemutation eyeless (e). The mutations e and b are alleles oftwo different genes that are known to be very closelylinked on the tiny autosomal chromosome 4. All the progeny had a wild-type phenotype. One of the female progeny was crossed with a male of genotype b e/b e ; we willcall this cross 2. Most of the progeny of cross 2 were of theexpected types, but there was also one rare female ofwild-type phenotype.a. Explain what the common progeny are expected tobe from cross 2.b. Could the rare wild-type female have arisen by (1)crossing over or (2) nondisjunction? Explain.arrow_forwardFemale fruit flies homozygous for the X-linked white-eye alleleare crossed to males with red eyes. On very rare occasions, an offspringof such a cross is a male with red eyes. Assuming these rareoffspring are not due to a new mutation in one of the mother’s Xchromosomes that converted the white-eye allele into a red-eyeallele, explain how a red-eyed male arises.arrow_forwardThe maternal-effect mutation bicoid (bcd) is recessive. Inthe absence of the bicoid protein product, embryogenesis isnot completed. Consider a cross between a female heterozygousfor the bicoid mutation (bcd+/ bcd-) and a homozygousmale(bcd-/ bcd-). How is it possible for a male homozygous for the mutationto exist?arrow_forward
- A Drosophila male is heterozygous for a reciprocaltranslocation between an autosome and the Y chromosome. The part of the autosome now present onthe Y chromosome contains the dominant mutationLyra (shortened wings); the other (normal) copyof the same autosome is Lyra+. This male is nowmated with a true-breeding, wild-type female. Whatkinds of progeny would be obtained, and in whatproportions?arrow_forwardOn rare occasions, an organism may have three copies of achromosome and therefore has three copies of the genes on thatchromosome (instead of the usual number of two copies). Forsuch a rare organism, the alleles for each gene usually segregateso that a gamete will contain one or two copies of the gene. Let’ssuppose that a rare pea plant has three copies of the chromosomethat carries the height gene. Its genotype is TTt. The plant is alsoheterozygous for the seed color gene, Yy, which is found on adifferent chromosome. With regard to both genes, how manytypes of gametes can this plant make, and in what proportions?(Assume that it is equally likely that a gamete will contain oneor two copies of the height gene.)arrow_forwardIn Neurospora, his2 mutants require the amino acidhistidine for growth, and lys4 mutants require theamino acid lysine. The two genes are on the samearm of the same chromosome, in the ordercentromere - his2 - lys4.A his2 mutant is mated with a lys4 mutant. Draw all ofthe possible ordered asci that could result from meioses in which the following events occurred, accountingfor the nutritional requirements for each ascospore.Ascospores without any copy of a chromosome willabort and die, turning white in the process.a. A single crossover between the centromere and his2b. A single crossover between his2 and lys4c. Nondisjunction during the first meiotic divisiond. Nondisjunction during the second meiotic divisione. A single crossover between the centromere andhis2, followed by nondisjunction during the firstmeiotic divisionf. A single crossover between his2 and lys4,followed by nondisjunction during the firstmeiotic divisionarrow_forward
- The karyotype of a young girl who is affected with familialDown syndrome revealed a total of 46 chromosomes. Her olderbrother, however, who is phenotypically unaffected, actually had45 chromosomes. Explain how this could happen. What wouldyou expect to be the numbers of chromosomes in the parents ofthese two children?arrow_forwardIn a vial of Drosophila, a research student noticedseveral female flies (but no male flies) with bag wingseach consisting of a large, liquid-filled blister insteadof the usual smooth wing blade. When bag-wingedfemales were crossed with wild-type males, 1/3 of theprogeny were bag-winged females, 1/3 were normalwinged females, and 1/3 were normal-winged males.Explain these results.arrow_forwardDrosophila may be monosomic for chromosome 4, yet remain fertile.Contrast the F1 and F2 results of the following crosses involvingthe recessive chromosome 4 trait, bent bristles:(a) monosomic IV, bent bristles * normal bristles;(b) monosomic IV, normal bristles * bent bristles.arrow_forward
- Consider two hypothetical recessive autosomal genesa and b, where a heterozygote is testcrossed to a doublehomozygousmutant. Predict the phenotypic ratios underthe following conditions:(a) a and b are located on separate autosomes.(b) a and b are linked on the same autosome but areso far apart that a crossover always occurs betweenthem.(c) a and b are linked on the same autosome but are soclose together that a crossover almost never occursarrow_forwardIn individuals affected by cystic fibrosis, salt crystals may appear afterperspiration dries up. In addition, the disease causes respiratory disorderswhich can be both debilitating and lethal. It occurs in individuals homozygousfor the recessive gene. Two normal parents had a daughter with thesymptoms of this disease, and a normal son who marries a normal womanwith an afflicted A test (salt concentration in perspiration of heterozygotes ishigher than normal) disclosed that both are indeed carriers of the gene. If thefirst child born to the mating in (b) was defective, what is the probability thatthe 2nd child would also be defective?Express answer in fraction formarrow_forwardA cytogeneticist has collected tissue samples from members of acertain butterfly species. Some of the butterflies were located inCanada, and others were found in Mexico. Through karyotyping,the cytogeneticist discovered that chromosome 5 of the Canadianbutterflies had a large inversion compared with chromosome 5 ofthe Mexican butterflies. The Canadian butterflies were inversionhomozygotes, whereas the Mexican butterflies had two normalcopies of chromosome 5.Explain whether a mating between Canadian and Mexicanbutterflies would produce phenotypically normal offspring?arrow_forward
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