Essentials of Genetics Plus Mastering Genetics with eText -- Access Card Package (9th Edition) (Klug et al. Genetics Series)
9th Edition
ISBN: 9780134047201
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 13, Problem 18PDQ
Shown in the following table are several amino acid substitutions in the α and β chains of human hemoglobin. Use the genetic code table in Figure 12–7 to determine how many of them can occur as a result of a single
| Hb Type | Normal Amino Acid | Substituted Amino Acid |
| HbJ Toronto | Ala | Asp (α-5) |
| HbJ Oxford | Gly | Asp (α-15) |
| Hb Mexico | Gln | Glu (α-54) |
| Hb Bethesda | Tyr | His (β-145) |
| Hb Sydney | Val | Ala (β-67) |
| HbM Saskatoon | His | Tyr (β-63) |
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Shown below are two homologous lengths of the alpha and betachains of human hemoglobin. Consult a genetic code dictionary and determine how many amino acid substitutionsmay have occurred as a result of a single nucleotidesubstitution. For any that cannot occur as a result of a singlechange, determine the minimal mutational distance.
Alpha: ala val ala his val asp asp met proBeta: gly leu ala his leu asp asn leu lys
A normal hemoglobin protein has a glutamic acid at position 6; in sickle-cell hemoglobin, this glutamic acid has been replaced by a valine. List all the possible mRNA codons that could be present for each type of hemoglobin. Can a single base change result in a change from Glu to Val in hemoglobin?
The amino acid glycine is encoded by four codons: GGA, GGC, GGG, and GGU.
Which of the following statements correctly explains this fact?
The glycine anticodon contains the sequence CC, but the 5' base of the anticodon can pair nonspecifically with the 3' base of the codon.
The glycine anticodon contains the sequence CC, but the 3' base of the anticodon can pair nonspecifically with the 5' base of the codon.
Glycine tRNA has four anticodons, and the appropriate anticodon specifically pairs with the correct codon.
There are four tRNAs for glycine, each of which has an anticodon that specifically pairs with the correct codon.
all of the above
Chapter 13 Solutions
Essentials of Genetics Plus Mastering Genetics with eText -- Access Card Package (9th Edition) (Klug et al. Genetics Series)
Ch. 13 - CASE STUDY | Crippled ribosomes Diamond Blackfan...Ch. 13 - CASE STUDY | Crippled ribosomes Diamond Blackfan...Ch. 13 - Prob. 3CSCh. 13 -
HOW DO WE KNOW?
1. In this chapter, we focused on...Ch. 13 - Review the Chapter Concepts list on p. 238. These...Ch. 13 - List and describe the role of all molecular...Ch. 13 - Contrast the roles of tRNA and mRNA during...Ch. 13 - Francis Crick proposed the adaptor hypothesis for...Ch. 13 -
6. During translation, what molecule bears the...Ch. 13 - Summarize the steps involved in charging tRNAs...
Ch. 13 - Each transfer RNA requires at least four specific...Ch. 13 -
9. Explain why the one-gene:one-enzyme hypothesis...Ch. 13 - Prob. 10PDQCh. 13 - Prob. 11PDQCh. 13 - Prob. 12PDQCh. 13 - Assuming that each nucleotide is 0.34 nm long in...Ch. 13 - Review the concept of colinearity in Section 12.5...Ch. 13 -
15. In your opinion, which of the four levels of...Ch. 13 -
16. List and describe the function of as many...Ch. 13 - How does an enzyme function? Why are enzymes...Ch. 13 -
18. Shown in the following table are several...Ch. 13 -
19. Three independently assorting genes are known...Ch. 13 -
20. How would the results in cross (a) of Problem...Ch. 13 - A series of mutations in the bacterium Salmonella...Ch. 13 -
22. The emergence of antibiotic-resistant strains...
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