Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
7th Edition
ISBN: 9781464126116
Author: David L. Nelson, Michael M. Cox
Publisher: W. H. Freeman
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Chapter 14, Problem 11P
Summary Introduction

To determine: Whether the skeletal muscle can carry out strenuous physical activity if they were devoid of lactate dehydrogenase.

Introduction:

“Anaerobic harvest” of food energy is known as fermentation. The continuous supply of oxygen generated from cellular respiration allows continuous movement of muscles. In the absence or shortage of oxygen when muscle spends ATP at faster rate than the muscles starts working anaerobically to synthesis ATP molecules.

The intense workout by muscles utilizes oxygen from the blood at faster rate causing decrease in level of oxygen for other reactions. Then, the molecule of glucose is converted into pyruvic acid in the absence of oxygen to produce two molecules of ATP which keeps the muscle going. End product of this reaction is lactic acid.

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