BIOCHEM-ACHIEVE(FIRST DAY DISCOUNTED)
BIOCHEM-ACHIEVE(FIRST DAY DISCOUNTED)
9th Edition
ISBN: 2818000069358
Author: BERG
Publisher: MAC HIGHER
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Chapter 14, Problem 16P
Interpretation Introduction

Interpretation:

Number of cAMP molecules produced from the complex of epinephrine and beta-adrenergic receptor should be determined.

Concept introduction:

The adrenergic receptors are the GPCRs (G-proteins coupled receptors), whose ligands are basically epinephrine and norepinephrine hormones produced by the body. Beta blockers, ß2 agonists and a2 agonists are certain medicines that also bind to the adrenergic receptors, to cure asthma and high blood pressure.

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Assighment. Create a diagram which illustrates the typical signalling mechanism of action of each of the four common classes of receptor (e.g. kinase-linked receptors etc.) and possible routes of communication (autocrine etc.). Your diagram should show the specific molecules involved, the mechanisms of signal transduction and indicate the different pathways that are activated. It should include a specific example of a receptor, ligand and signalling pathway for each general class. Include as wide a variety of ligands and modes of action as you can. For each of the examples describe the mechanism of action in the form below. DO NOT use any of the ligand-receptor combinations provide to you in the Learning Materials to date - research and create a diagram for a novel pathway instead!
True or False. The binding affinity between a peptide agonist and its specific G protein coupled receptor alone determines the sensitivity of a cell to the agonist peptide.
Question. Explain the signal transduction mechanism for slow ligand-gated ion channels.
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