BIOCHEMISTRY W/1 TERM ACHEIVE ACCESS
9th Edition
ISBN: 9781319425746
Author: BERG
Publisher: MAC HIGHER
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 14, Problem 17P
Interpretation Introduction
Interpretation:
Mechanism for NGF signaling pathways and the secondary messenger produced during this should be determined.
Concept introduction:
Nerve growth factor is a neuropeptide that is responsible for the growth, proliferation, maintenance, and survival of the certain target neurons. NGF binds to two kinds of receptors, tropomyosin receptor kinase A, and low-affinity NGF receptor. The mutation in any of these receptors can lead to neurodegenerative disorders.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Inducers and Inhibitors of AEP.
Short peptides such as legumain stabilization and activity modulation (LSAM) domain and αvβ3 integrin could enhance the activity of AEP. LSAM domain known as the prodomain of AEP blocks substrate binding before activation. This prodomain has a helical structure and two independent peptides. One is an activation peptide (AP, K287 to N323), and the other is a LSAM domain. LSAM domain remains even after AP is cleaved and released from protease at neutral pH via electrostatic interaction. AEP without LSAM domain has a lower melting temperature than AEP with LSAM domain [77, 117]. Another short peptide, αvβ3 integrin, can directly interact with AEP, and after forming a complex, the optimal pH for AEP activity is increased from 5.5 to 6.0. It indicates that αvβ3 binding could induce conformational stabilization of AEP accompanied by deprotonated C189. αvβ3 does not directly interact with the AEP active site; however, AEP docks to the αvβ3 RGD-binding site…
Cell signaling.
The ER doctors gave a patient an injection of epinephrine to increase his heart rate and blood pressure. The heart rate and blood pressure went up but not enough. The second dose of the same drug seemed not to have an effect. What do you think may be a possible explanation for this result?
SIGNALS AND TARGETS. Listed below are sample polypeptides/proteins with their signal molecule/peptide. Answer the questions that follow. If you are asked to give the amino acid sequence, provide the sequence using the three-letter names of the amino acids (eg. ser-ala-met).
Catalase with H2N-...KERINGKERIANGEKSAMSKL-COOH
What is the name of the specific receptor of this polypeptide?
The receptor may also have what alternative function?
Chapter 14 Solutions
BIOCHEMISTRY W/1 TERM ACHEIVE ACCESS
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Please help me with this question. More than one answer may be correct. THe graph relating to the information is included below. The above figures show the rate of actin polymerization in the presence of various concentration of profilin (Pfn). In the top figure, flourescence intensity is a measure of total actin that has been polymerized, and this is plotted versus time in seconds. The shade of blue of the lines in the top figure correspond to the shaded blue bars representing various concentrations of profilin in the lower figure. The lower graph shows the initial rates of polymerization of actin plotted again concentration. Which of the following is true: Question 21 options: profilin in a molecular motor profilin is a promoter of actin polymerization profilin replaced G-actin in an F-actin strand and breaks the filament profilin is an inhibitor of actin polymerization profilin binds to G-actin, preventing it from polymerizingarrow_forwardTrue or False. The binding affinity between a peptide agonist and its specific G protein coupled receptor involves certain types of chemical bonds. Explain your answer in detail.. ( please do not copy off of another source.. e.g chegg)arrow_forward1G. Please help me in detail. For Molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Write an expression for the reaction velocity.arrow_forward
- Frog poison. Batrachotoxin (BTX) is a steroidal alkaloid from the skin of Phyllobates terribilis, a poisonous Colombian frog (the source of the poison used on blowgun darts). In the presence of BTX, Na+Na* channels in an excised patch stay persistently open when the membrane is depolarized. They close when the membrane is repolarized. Which transition is blocked by BTX?arrow_forwardTrue or False. The binding affinity between a peptide agonist and its specific G protein coupled receptor alone determines the sensitivity of a cell to the agonist peptide.arrow_forwardPlease help me with this question. PLEase give me the right answer and for number 2 WRITE AT LEAST A PARAGRAPGH and dont copy from internet.arrow_forward
- Ligand binding and response. The following question involves the ligand binding to a receptor and the receptor's response to that ligand. What ligand concentration would be required for a full agonist with a KD of 8 nM to achieve a response of 0.75?arrow_forward1H. please help me in detail. For molecular Mechanism of ATP versus GTP selectivity of adenylate kinasearrow_forwardSignal transduction pathway. Sketch a G protein in the active and inactive stages, and label its parts.arrow_forward
- Question. Explain the signal transduction mechanism for slow ligand-gated ion channels.arrow_forwardPlease help me with this question. More than one answer may be correct. THe graph relating to the information is included below. The figure shows the number of cells that have clusters of IRE1 molecules after those cells are treated with various levels of thapsigargin (Tg), a chemical that can induce ER stress. IRE1 can form these clusters when ER stress is induced and this clustering can cause activation of RNAse activity in IRE1. In this experiment, normal IRE1 was used (IRE1α) that can bind to Sec61, along with a modified version of IRE1 that binds to Sec61 more weakly than normal IRE1 (wIRE1α), and another modified version that binds to Sec61 more strongly than normal IRE1 (sIRE1α). From this figure you can conclude that: Question 18 options: IRE1 binding to Sec61 promotes the formation of IRE1 clumps IRE1 binding to Sec61 prevents the formation of IRE1 clumps co-translational translocation is a key process the golgi aparatus is heavily involved in the unfolded protein response The…arrow_forwardPlesae ASAP. thanku Which of the following is not true about the glutamate family of ligand-gated ion channels? a. members are AMPA, kinase, and NMDA channels b. they are cation permable c. channels subunits have 3 full transmembrane doamins d. they require 5 subunits to amke a functional channelarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning