IA MODIFIED MASTERING BIOLOGY WITH E TEX
IA MODIFIED MASTERING BIOLOGY WITH E TEX
12th Edition
ISBN: 9780136781752
Author: Urry
Publisher: PEARSON
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Chapter 1.4, Problem 2CC

MAKE CONNECTIONS Ø The gene that causes sickle-cell disease is present in a higher percentage of residents of sub-Saharan Africa than among those of African descent living in the United States. Even though this gene causes sickle-cell disease, it also provides some protection from malaria, a serious disease that is widespread in sub-Saharan Africa but absent in the United States. Discuss an evolutionary process that could account for the different percentages of the sickle-cell gene among residents of the two regions. (See Concept 1.2.)

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Steven Frank and Laurence Hurst argued that a cytoplasmically inherited mutation in humans that has severe effects in males but no effect in females will not be eliminated from a population by natural selection because only females pass on mtDNA (S. A. Frank and L. D. Hurst. 1996. Nature 383:224). Using this argument, explain why males with Leber hereditary optic neuropathy are more severely affected than females.
Recall from our classes on molecular evolution that some proteins evolve more rapidly than others. For example, the oxygen-carrying protein myoglobin evolves more quickly than the D1 protein of photosystem II.  What explains this difference in the rate of protein evolution?  A. Proteins like myoglobin have evolved more recently than proteins like D1 and thus have been forced to evolve more quickly. B. Changes to the sequence of some proteins can be tolerated as they don’t alter fitness; for other proteins, sequence changes are usually harmful. C. In constrained proteins like D1, evolution results primarily from nucleotide changes that alter the amino acid sequence of the protein.  D. Protein evolution is dependent upon the rate of gene mutation and some genes have a higher rate of mutation than others.
Following a gene duplication, two genes will accumulate different mutations, causing them to have slightly different sequences. In Figure 8.7, which pair of genes would you expect to have more similar sequences: α1 and α2 or ψα1 and α2? Explain your answer.
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