CAMPBELL BIOLOGY IN FOCUS (LL)-W/MOD.MA
3rd Edition
ISBN: 9780135686065
Author: Urry
Publisher: PEARSON
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Textbook Question
Chapter 14.3, Problem 3CC
WHAT IF? What would be the effect of treating cells with an agent that removed the cap from mRNAs?
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E22. The method of Northern blotting is used to determine the amount
and size of a particular RNA transcribed in a given cell type.
Alternative splicing (discussed in Chapter 12) produces mRNAs
of different lengths from the same gene. The Northern blot shown
here was made using a DNA probe that is complementary to the
MRNA encoded by a particular gene. The mRNA in lanes 1 through
4 was isolated from different cell types, and equal amounts of total
cellular MRNA were added to each lane.
2
3
4
Lane 1: MRNA isolated
from nerve cells
Lane 2: MRNA isolated
from kidney cells
Lane 3: MRNA isolated
from spleen cells
Lane 4: MRNA isolated
from muscle cells
Explain these results.
| |
MRNA- based therapeutics
The following questions:
Which research group has initially developed the technology?
What was the purpose behind the invention of the technology?
What type of questions could be answered with the technology?
What are the applications of the technology?
Are there any clinical trials associated with the method?
What is the mechanism of action for the technology?
Q34. mRNA decay (breakdown) can play an important role in controlling protein abundance.
Which of the following scenarios correctly describes a relationship between mRNA decay and protein abundance?
A. A decrease in transcription with an increase in the rate of mRNA decay can result in increased protein abundance.
B. An increase in transcription with an increase in the rate of mRNA decay can result in no change in protein abundance.
C. An increase rate of protein synthesis but failure to form an apoprotein can be explained by a decrease in mRNA decay.
D. None of the above
Chapter 14 Solutions
CAMPBELL BIOLOGY IN FOCUS (LL)-W/MOD.MA
Ch. 14.1 - MAKE CONNECTIONS In a research article about...Ch. 14.1 - What polypeptide product would you expect from a...Ch. 14.1 - DRAW IT The template strand of a gene contains the...Ch. 14.2 - What is a promoter? Is it located at the upstream...Ch. 14.2 - What enables RNA polymerase to start transcribing...Ch. 14.2 - WHAT IF? Suppose X-rays caused a sequence change...Ch. 14.3 - Given that there are about 20,000 human genes, how...Ch. 14.3 - How is RNA splicing similar to how you would watch...Ch. 14.3 - WHAT IF? What would be the effect of treating...Ch. 14.4 - What two processes ensure that the correct amino...
Ch. 14.4 - Discuss the ways in which rRNA structure likely...Ch. 14.4 - Describe how a polypeptide to be secreted is...Ch. 14.4 - WHAT IF? DRAW IT Draw a tRNA with the anticodon...Ch. 14.5 - What happens when one nucleotide pair is lost from...Ch. 14.5 - Prob. 2CCCh. 14.5 - WHAT IF? DRAW IT The template strand of a gene...Ch. 14 - In eukaryotic cells, transcription cannot begin...Ch. 14 - Prob. 2TYUCh. 14 - The anticodon of a particular tRNA molecule is A....Ch. 14 - Prob. 4TYUCh. 14 - Which component is not directly involved in...Ch. 14 - Prob. 6TYUCh. 14 - Prob. 7TYUCh. 14 - Prob. 8TYUCh. 14 - Prob. 9TYUCh. 14 - SCIENTIFIC INQUIRY Knowing that the genetic code...Ch. 14 - Prob. 11TYUCh. 14 - FOCUS ON INFORMATION Evolution accounts for the...Ch. 14 - SYNTHESIZE YOUR KNOWLEDGE Some mutations result in...
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- please help, will rate! What is the difference between obligate and non-obligate chain terminating nucleotides? How were sofosbuvir and remdesivir modified to make them non-obligate terminators?arrow_forwardWhat are the differences between protein subunit vaccines and mRNA vaccines?” “2. What is the minimal inhibitory concentration (MIC, the question means in general, not of a specific drug)? Why might different bacteria have different MICs to different drugs?” “3. Knowing what you know now about misuse of antibiotics, is it beneficial or harmful to stop including the antiseptic triclosan in soaps?”arrow_forwardYes or no? Is sequence of riboprobe identical to the mrna produced by gene in situ hybridization? does column of purification in DNA allow it to flow while other molecules are trapped ?arrow_forward
- Recall from the central dogma that DNA codes for mRNA, which then codes for protein. Also recall that directionality matters! DNA 3' TAC - CTA -AAT - TGC - TCG-ATT 5' mRNA 5' ???- ???- ???- ???- ???- ??? 3' protein ? ? ? ? ? (A) Indicate whether the DNA sequence provided is the sense strand or the antisense strand. ? that (B) For the DNA sequence given above, write out the mRNA sequence that results. (C) Now write the amino acid sequence that results from the mRNA sequence you wrote in part (B). Use the three-letter abbreviations for the amino acids. (D) What happens if the A that is bolded and underlined in the given DNA sequence is mutated (changed) to a C? How is the protein affected? This can be answered in a few words, but be specific! (E) Now let's pretend for a moment that the protein being affected is ATP-ADP translocase. What, if anything, would happen to the citric acid cycle? This should be answered in a few words/one sentence max.arrow_forwardE32. In the technique of DNase I footprinting, the binding of a protein to a region of DNA protects that region from digestion by DNase I by blocking the ability of DNase I to gain access to the DNA. In the DNase I footprinting experiment shown here, a researcher began with a sample of cloned DNA 400 bp in length. This DNA contained a eukaryotic promoter for RNA polymerase II. The assembly of general transcription factors and RNA polymerase II at the core promoter is described in Chapter 12 (see Figure 12.14). For the sample loaded in lane 1, no proteins were added. For the sample loaded in lane 2, the 400-bp fragment was mixed with RNA polymerase II plus TFIID and TFIIB. 2 400 350 250 175 50 Which region of this 400-bp fragment of DNA is bound by RNA polymerase II and TFIID and TFIIB? || III ||| | ||||arrow_forwardAnswer as Directed. Below is the model of a lac operon. lac I lac Z с promoter operator +1 lac Y lac A DNA 1. In the absence of lactose and the presence of glucose in the bacterial growth media, what proteins are bound to the lac control region? Is the operon being transcribed then? 2. In the presence of lactose and the presence of glucose in the bacterial growth media, what proteins are bound to the lac regulatory region? Is the operon being transcribed then? 3. In the presence of lactose and the absence of glucose in the bacterial growth media, what proteins are bound to the lac control region? 4. Why is it adaptive for a bacterium to not express the genes that encode for that lactose utilization proteins when lactose is not available or when glucose is present? 5. Why is it adaptive for the structural genes for using lactose to be under the control of a single promoter, i.e., synthesize a polycistronic message rather than three monocistronic message?arrow_forward
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