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EBK LIFE: THE SCIENCE OF BIOLOGY
11th Edition
ISBN: 8220103935432
Author: Sadava
Publisher: MAC HIGHER
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Chapter 14.4, Problem 2R
Summary Introduction
To review:
The steps for ribonucleic acid (RNA) splicing and the consequence, if it fails to occur in the cell correctly.
Introduction:
In a prokaryotic cell, messenger RNA (mRNA) molecule that is synthesized contains a continuous sequence of codons that are used to synthesize the proteins. On the contrary, in case of eukaryotes, the transcript has introns that do not code for any protein. These are placed between the coding sequences called exons. Therefore, in the eukaryotes, splicing occurs to remove these intronic regions, which is the last step of the posttranscriptional modification.
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Describe the process of RNA splicing, including the roles of the spliceosome and self-splicing RNA molecules.
Why is alternative splicing beneficial?
Consider the CT/CGRP example of alternative splicing. Which different types of alternative splicing patterns are represented?
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EBK LIFE: THE SCIENCE OF BIOLOGY
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- What is alternative splicing? What is its biological significance?arrow_forwardDraw the SMN2 pre-mRNA (10 exons and 9 introns), indicate the 5’ and 3’ SS location. Draw the SMN2 mature mRNA before treatment with Spinraza. What type of alternative splicing is occurring? Draw the SMN2 mature mRNA after treatment with Spinrazaarrow_forwardList three types of alternative splicing patterns and how they lead to the production of different protein isoforms.arrow_forward
- What is a disorder caused by errors in transcription? What kind of error is involved?arrow_forwardA gene contains eight sites where alternative splicing is possible. Assuming that the splicing pattern at each site is independent of that at all other sites, how many splicing products are possible?arrow_forwardDraw the SMN2 mature mRNA before treatment with Spinraza. What type of alternative splicing is occurring?arrow_forward
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